Immune-endocrine biomarkers associated with mental health: A 9-year longitudinal investigation from the Hertfordshire Ageing Study

被引:7
作者
Hou, Ruihua [1 ]
Westbury, Leo [2 ]
Fuggle, Nicholas [2 ,3 ]
Cooper, Cyrus [2 ,4 ,5 ,6 ]
Dennison, Elaine [2 ,4 ,5 ,7 ]
机构
[1] Univ Southampton, Fac Med, Dept Psychiat Clin & Expt Sci, Southampton, Hants, England
[2] Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England
[3] Alan Turing Inst, London, England
[4] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England
[5] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
[6] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England
[7] Victoria Univ Wellington, Wellington, New Zealand
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
Psychoneuroimmunology; Inflammation; The hypothalamic-pituitary-adrenal axis; C-reactive protein; Cortisol; Mental health; Depression; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; DEPRESSIVE SYMPTOMS; DEHYDROEPIANDROSTERONE-SULFATE; MAJOR DEPRESSION; SEX-DIFFERENCES; LATE-LIFE; STRESS; CORTISOL; PSYCHONEUROIMMUNOLOGY;
D O I
10.1016/j.bbi.2021.12.022
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: The study of neural-endocrine-immune system interactions has led to substantial advances in our understanding of neuropsychiatric disorders. Growing evidence reveals the pivotal roles of inflammatory cytokines signalling the brain to produce neurochemical, neuroendocrine, and neuroimmune changes which affect mood and behaviour. Ageing is accompanied by the development of low-grade systemic inflammation which may promote changes in the neural systems predisposing to geriatric depression via the hypothalamic-pituitaryadrenal (HPA) axis. The aim of this study was to investigate the longitudinal associations between baseline values and conditional changes (independent of baseline) in immune-endocrine biomarkers and mental health status in a population-based cohort of older adults. Methods: Data from 347 subjects (200 men, 147 women) who participated in the Hertfordshire Ageing Study at baseline (1994/5, mean age 67.3 years) and at 9-year follow-up were analysed. Serum samples for analysis of inflammatory and endocrinological measures were collected at baseline and follow-up. At follow-up, depression (Hospital Anxiety and Depression Scale) and mental health (Short Form-36 questionnaire) were assessed. Baseline values and changes in biomarkers in relation to risk of high depression scores (top sex-specific third) and low mental health scores (bottom sex-specific third) were examined using logistic regression. Results: Lower baseline cortisol was related to greater risk of high depression scores; higher baseline cortisol: dehydroepiandrosterone sulphate ratio (men only) and higher baseline C-reactive protein (CRP) (women only) were related to greater risk of poor mental health scores. In addition, greater decline in cortisol was related to increased risk of high depression scores among men. These relationships were robust (p < 0.05) after controlling for sex, age, BMI, smoking, alcohol consumption and number of systems medicated. Conclusion: This study provides further evidence of the role of the HPA axis and inflammation in older adults with poor mental health. In addition, the findings highlight sex differences where increased inflammation in women and declines in cortisol in men were linked to poorer mental health. Further research is warranted to confirm these findings. This could lead to the search for potential biomarkers to stratify medications as well as developing novel intervention targets to improve mental health at older age.
引用
收藏
页码:146 / 152
页数:7
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