Paternal age and telomere length in twins: the germ stem cell selection paradigm

被引：38

作者：

Hjelmborg, Jacob B. ^{[1
,2
]}

Dalgard, Christine ^{[3
]}

Mangino, Massimo ^{[4
]}

Spector, Tim D. ^{[4
]}

Halekoh, Ulrich ^{[1
]}

Moller, Soren ^{[1
]}

Kimura, Masayuki ^{[5
]}

Horvath, Kent ^{[5
]}

Kark, Jeremy D. ^{[6
]}

Christensen, Kaare ^{[1
,2
]}

Kyvik, Kirsten O. ^{[7
,8
]}

Aviv, Abraham ^{[5
]}

机构：

[1] Univ Southern Denmark, Inst Publ Hlth, Dept Epidemiol Biostat & Biodemog, DK-5000 Odense, Denmark

[2] Univ Southern Denmark, Danish Twin Registry, DK-5000 Odense, Denmark

[3] Univ Southern Denmark, Inst Publ Hlth, Dept Environm Med, DK-5000 Odense, Denmark

[4] Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[5] Rutgers State Univ, New Jersey Med Sch, Ctr Human Dev & Aging, Newark, NJ 07103 USA

[6] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Epidemiol Unit, IL-91120 Jerusalem, Israel

[7] Univ Southern Denmark, Inst Reg Hlth Serv Res, Odense, Denmark

[8] Odense Univ Hosp, Odense Patient Data Explorat Network OPEN, DK-5000 Odense, Denmark

来源：

AGING CELL | 2015年 / 14卷 / 04期

关键词：

telomeres; twins; father's age; germ line; heritability; leukocytes; MALE-DRIVEN EVOLUTION; DYNAMICS; TISSUES;

D O I：

10.1111/acel.12334

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.

引用

页码：701 / 703

页数：3

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