Face and gaze perception in borderline personality disorder: An electrical neuroimaging study

被引：15

作者：

Berchio, Cristina ^{[1
]}

Piguet, Camille ^{[1
,2
]}

Gentsch, Kornelia ^{[2
,3
]}

Kung, Anne-Lise ^{[2
,3
]}

Rihs, Tonia A. ^{[1
]}

Hasler, Roland ^{[2
,3
]}

Aubry, Jean-Michel ^{[2
,3
]}

Dayer, Alexandre ^{[1
,2
,3
]}

Michel, Christoph M. ^{[1
,4
]}

Perroud, Nader ^{[2
,3
]}

机构：

[1] Univ Geneva, Dept Basic Neurosci, Geneva, Switzerland

[2] Univ Hosp Geneva, Mood Disorders Unit, Serv Psychiat Specialties, Dept Mental Hlth & Psychiat, Geneva, Switzerland

[3] Univ Geneva, Dept Psychiat, Geneva, Switzerland

[4] Biomed Imaging Ctr CIBM Lausanne, Geneva, Switzerland

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2017年 / 269卷

基金：

瑞士国家科学基金会;

关键词：

Borderline patients; Neutral faces; Memory; ERP; EEG source imaging; EVENT-RELATED POTENTIALS; SUPERIOR FRONTAL GYRUS; FACIAL EMOTION; FUSIFORM GYRUS; BRAIN RESPONSES; AVERTED GAZE; TIME-COURSE; RECOGNITION; ANTERIOR; AMYGDALA;

D O I：

10.1016/j.pscychresns.2017.08.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD.

引用

页码：62 / 72

页数：11

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