Fabrication of porous calcium phosphate cements using gelatin as porogen

被引：7

作者：

Lee, Jong-Hoon ^{[2
]}

Kim, Hyoun-Ee ^{[2
]}

Koh, Young-Hag ^{[1
]}

机构：

[1] Korea Univ, Dept Dent Lab Sci & Engn, Seoul 136703, South Korea

[2] Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 151742, South Korea

来源：

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN | 2010年 / 118卷 / 1373期

关键词：

Porosity; Mechanical properties; Biomedical applications; Bone cements; Calcium phosphate; MACROPORES; FIBER;

D O I：

10.2109/jcersj2.118.34

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous calcium phosphate cements (CPCs) were fabricated using gelatin granules as the porogen. As the amount of gelatin was increased front 0 to 43 vol%, the porosity notably increased from 3 to 47 vol%, while the compressive strength decreased from 23 to 14 MPa; however, these values are still expected to be reasonably high for applications in bone tissue engineering. In addition, osteoblastic cells grew favorably on the surfaces of the CPCs prepared using gelatin of 11 and 43 vol%, which contained well interconnected pores with a size of several hundreds of microns, indicating excellent biocompatibility of the porous CPC samples produced in this study. (C)2010 The Ceramic Society of Japan. All rights reserved.

引用

页码：34 / 36

页数：3

共 18 条

[1] In vivo behavior of three different injectable hydraulic calcium phosphate cements [J].

Apelt, D ;

Theiss, F ;

El-Warrak, AO ;

Zlinszky, K ;

Bettschart-Wolfisberger, R ;

Bohner, M ;

Matter, S ;

Auer, JA ;

von Rechenberg, B .

BIOMATERIALS, 2004, 25 (7-8) :1439-1451

[2] Effect of added gelatin on the properties of calcium phosphate cement [J].

Bigi, A ;

Bracci, B ;

Panzavolta, S .

BIOMATERIALS, 2004, 25 (14) :2893-2899

[3] A water setting tetracalcium phosphate-dicalcium phosphate dihydrate cement [J].

Burguera, EF ;

Guitián, F ;

Chow, LC .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 71A (02) :275-282

[4]

Constantz BR, 1998, J BIOMED MATER RES, V43, P451, DOI 10.1002/(SICI)1097-4636(199824)43:4<451::AID-JBM13>3.3.CO

[5]

2-H

[6] A new method to produce macropores in calcium phosphate cements [J].

del Real, RP ;

Wolke, JGC ;

Vallet-Regí, M ;

Jansen, JA .

BIOMATERIALS, 2002, 23 (17) :3673-3680

[7]

KOKUBO T, 1990, CRC HDB BIOACTIVE CE, P41

[8] Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles [J].

Link, Dennis P. ;

van den Dolder, Juliette ;

Jurgens, Wouter J. F. M. ;

Wolke, Joop G. C. ;

Jansen, John A. .

BIOMATERIALS, 2006, 27 (28) :4941-4947

[9]

Miyamoto Y, 1999, J BIOMED MATER RES, V48, P36, DOI 10.1002/(SICI)1097-4636(1999)48:1<36::AID-JBM8>3.0.CO

[10]

2-I

← 1 2 →