Antibacterial, osteogenic, and angiogenic activities of SrTiO3 nanotubes embedded with Ag2O nanoparticles

被引：48

作者：

Chen, Yi ^{[1
]}

Gao, Ang ^{[2
]}

Bai, Long ^{[1
]}

Wang, Yueyue ^{[1
]}

Wang, Xin ^{[1
]}

Zhang, Xiangyu ^{[1
]}

Huang, Xiaobo ^{[1
]}

Hang, Ruiqiang ^{[1
]}

Tang, Bin ^{[1
]}

Chu, Paul. K. ^{[2
]}

机构：

[1] Taiyuan Univ Technol, Res Inst Surface Engn, Taiyuan 030024, Peoples R China

[2] City Univ Hong Kong, Dept Phys & Mat Sci, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 75卷

基金：

中国国家自然科学基金;

关键词：

TiO2; nanotubes; Strontium; Silver; Bacterial resistance; Angiogenesis; Osteogenesis; TIO2; NANOTUBES; SURFACE FUNCTIONALIZATION; STRONTIUM RANELATE; TITANIUM-ALLOY; OSTEOBLAST; VEGF; OSSEOINTEGRATION; IMPLANT; DIFFERENTIATION; EXPRESSION;

D O I：

10.1016/j.msec.2017.03.014

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Biomedical titanium (Ti) implants with good anti-infective, osteogenic, and angiogenic properties are in great demand. SrTiO3 nanotubes (NTs) are embedded with silver oxide (Ag2O) nanoparticles (NPs) (denoted as NT-Sr-Ag) by a hydrothermal treatment of TiO2 NTs containing Ag2O NPs (denoted as NT-Ag) in a Sr(OH)(2) solution. The morphology, composition, microstructure, ion release phenomenon, as well as antibacterial, osteogenic, and angiogenic activities are investigated in details. During the hydrothermal treatment, the amorphous TiO2 in the NTs morphs into cubic SrTiO3 gradually and the ordered nanotubular architecture is preserved. Some Ag2O NPs are incorporated into the structure although some of them dissolve in the solution. Long-term bacterial resistance against Staphylococcus aureus is observed as a result of the prolonged and controllable Ag+ release. NT-Sr-Ag can also release Sr2+ similarly to stimulate osteoblasts to secrete the vascular endothelial growth factor (VEGF). Both the released Sr2+ and secreted VEGF upregulate the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of osteoblasts. Furthermore, better angiogenic activity is observed when endothelial cells are cultured in NT-Sr-Ag conditioned media when compared with that in NT-Ag conditioned media, which is believed to be ascribed to the positive regulation of VEGF secretion of Sr2+.NT-2Sr-Ag and NT-3Sr-Ag (Hydrothermal treatment for 2 and 3 h, respectively) exhibit excellent antibacterial, osteogenic, and angiogenic activities and are promising in biomedical implants. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1049 / 1058

页数：10

共 54 条

[11] Angiogenesis in life, disease and medicine [J].

Carmeliet, P .

NATURE, 2005, 438 (7070) :932-936

[12] Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation [J].

Chen, Zetao ;

Yi, Deliang ;

Zheng, Xuebin ;

Chang, Jiang ;

Wu, Chengtie ;

Xiao, Yin .

JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (36) :6030-6043

[13] Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion [J].

Chua, Poh-Hui ;

Neoh, Koon-Gee ;

Kang, En-Tang ;

Wang, Wilson .

BIOMATERIALS, 2008, 29 (10) :1412-1421

[14] In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor [J].

Coulombe, J ;

Faure, H ;

Robin, B ;

Ruat, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 323 (04) :1184-1190

[15] Effect of reactive oxygen species overproduction on osteogenesis of porous titanium implant in the present of diabetes mellitus [J].

Feng, Ya-Fei ;

Wang, Lin ;

Zhang, Yang ;

Li, Xiang ;

Ma, Zhen-Sheng ;

Zou, Ji-Wei ;

Lei, Wei ;

Zhang, Zhi-Yong .

BIOMATERIALS, 2013, 34 (09) :2234-2243

[16] The biology of VEGF and its receptors [J].

Ferrara, N ;

Gerber, HP ;

LeCouter, J .

NATURE MEDICINE, 2003, 9 (06) :669-676

[17] The effects of titania nanotubes with embedded silver oxide nanoparticles on bacteria and osteoblasts [J].

Gao, Ang ;

Hang, Ruiqiang ;

Huang, Xiaobo ;

Zhao, Lingzhou ;

Zhang, Xiangyu ;

Wang, Lin ;

Tang, Bin ;

Ma, Shengli ;

Chu, Paul K. .

BIOMATERIALS, 2014, 35 (13) :4223-4235

[18] Antibacterial activity and cytocompatibility of Cu-Ti-O nanotubes [J].

Hang, Ruiqiang ;

Gao, Ang ;

Huang, Xiaobo ;

Wang, Xiaoguang ;

Zhang, Xiangyu ;

Qin, Lin ;

Tang, Bin .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (06) :1850-1858

[19] Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(L-lysine)-grafted-poly(ethylene glycol) copolymers [J].

Harris, LG ;

Tosatti, S ;

Wieland, M ;

Textor, M ;

Richards, RG .

BIOMATERIALS, 2004, 25 (18) :4135-4148

[20] Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo [J].

Hiltunen, MO ;

Ruuskanen, M ;

Huuskonen, J ;

Mähönen, AJ ;

Ahonen, M ;

Rutanen, J ;

Kosma, VM ;

Mahonen, A ;

Kröger, H ;

Ylä-Herttuala, S .

FASEB JOURNAL, 2003, 17 (06) :1147-+

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