Effector and memory T-cell differentiation: Implications for vaccine development

被引：1429

作者：

Kaech, SM

Wherry, EJ

Ahmed, R

机构：

[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1038/nri778

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent work shows that after stimulation with antigen, CD4(+) and CD8(+) T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programme of development and the factors that might influence its progression. Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the optimization of vaccine strategies.

引用

收藏

页码：251 / 262

页数：12

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