Aortic adventitial angiogenesis and lymphangiogenesis promote intimal inflammation and hyperplasia

被引：19

作者：

Xu, Xinsheng ^{[1
,2
,3
]}

Lu, Huixia ^{[1
,2
]}

Lin, Huili ^{[1
,2
,4
]}

Li, Xiaolu ^{[1
,2
,5
]}

Ni, Mei ^{[1
,2
]}

Sun, Huiwen ^{[1
,2
]}

Lin, Changjiang ^{[1
,2
]}

Jiang, Hong ^{[1
,2
]}

Li, Fuhai ^{[1
,2
]}

Zhang, Mei ^{[1
,2
]}

Zhao, Yuxia ^{[1
,2
]}

Zhang, Yun ^{[1
,2
]}

机构：

[1] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Chinese Minist Hlth, Jinan 250012, Shandong, Peoples R China

[3] Dongying Peoples Hosp, Dept Cardiol, Dongying, Shandong, Peoples R China

[4] Fujian Med Univ, Affiliated Hosp 2, Dept Cardiol, Fuzhou, Fujian, Peoples R China

[5] Qianfoshan Hosp, Dept Emergency, Jinan, Shandong, Peoples R China

来源：

CARDIOVASCULAR PATHOLOGY | 2009年 / 18卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Angiogenesis; Lymphangiogenesis; Intimal injury; Inflammation; ENDOTHELIAL GROWTH-FACTOR; BALLOON CATHETER INJURY; LESION FORMATION; PDGF-BB; HYALURONAN; MECHANISMS; LYVE-1; ATHEROSCLEROSIS; PROLIFERATION; ANGIOPLASTY;

D O I：

10.1016/j.carpath.2008.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Adventitial inflammation is known to influence neointimal formation and vascular remodeling. The present study was aimed to clarify the relationship between neointima hyperplasia and adventitial angiogenesis and lymphangiogenesis after balloon-induced aortic endothelial injury. Methods: Seventy male Wistar rats were randomly divided into six interventional groups and one control group. The intimal area/medial area ratio (I/M ratio), the adventitial macrophage index, and the number of adventitial microvessels (Ad-MV) and lymphatic vessels (Ad-LV) in the aorta were nicasured, and the mRNA expressions of VEGF-A, VEGFR-1, VEGF-C, VEGFR-3, PDGF-B, and PDGFR-beta in the aortic wall were quantified by real-time RT-PCR. Results: Compared with the control group, the I/M ratio, macrophage index, Ad-MV, Ad-LV, and the rnRNA expressions of VEGF-A, VEGFR-1, VEGF-C, VEGFR-3, PDGF-B, and PDGFR-beta in interventional groups increased significantly after balloon-induced injury. I/M ratio showed significant correlations with Ad-MV and Ad-LV after balloon intervention. Multiple linear regression analysis indicated that Ad-MV and Ad-LV were independent factors of intimal hyperplasia. Conclusion: Adventitial angiogenesis and lymphangiogenesis are induced by intimal inflammation after balloon injury, and these neogenetic vessels in turn promote intimal inflammation and hyperplasia probably via delivery and activation of inflammatory cells. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：269 / 278

页数：10

共 42 条

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