Oxidative Effects of Gemifloxacin on Some Biological Traits of Drosophila melanogaster (Diptera: Drosophilidae)

被引:20
作者
Aslan, Nilay [1 ]
Buyukguzel, Ender [1 ]
Buyukguzel, Kemal [2 ]
机构
[1] Zonguldak Bulent Ecevit Univ, Mol Biol & Genet Dept, TR-67100 Zonguldak, Turkey
[2] Zonguldak Bulent Ecevit Univ, Biol Dept, TR-67100 Zonguldak, Turkey
关键词
Drosophila melanogaster; gemifloxacin; survival; malondialdehyde; glutathione-S-transferase; DNA GYRASE INHIBITORS; LIFE-SPAN; ANTIOXIDATIVE RESPONSE; HYDROGEN-PEROXIDE; MIDGUT TISSUES; BORIC-ACID; LEPIDOPTERA; LONGEVITY; FECUNDITY; METABOLISM;
D O I
10.1093/ee/nvz039
中图分类号
Q96 [昆虫学];
学科分类号
摘要
In recent times, several studies have been undertaken on the artificial mass-rearing of insects in which clinical antibacterial antibiotics, including gemifloxacin, which is a DNA gyrase and topoisomerases inhibitor, are amended into the diet to control microbial contamination and preserve diet. The findings of these studies have suggested the possibility that these antibiotics influence the biological traits of insects in relation to their oxidative effects. This study investigated the effects of gemifloxacin on Drosophila melanogaster (Meigen) survival rates, development times, and male-female adult longevity. And we also determined the effects of gemifloxacin on lipid peroxidation product, malondialdehyde, protein carbonyl levels, and glutathione S-transferase activity of fruit fly eggs. First instars were fed on artificial diets containing 150, 300, 600, and 900 mg/liter concentrations of gemifloxacin until adult emergence. Our results indicate that sublethal effects of gemifloxacin are likely to significantly impair adult fitness and life-history parameters in D. melanogaster, probably because of its oxidative effects.
引用
收藏
页码:667 / 673
页数:7
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