Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration

被引：63

作者：

Olson, Thomas A. ^{[1
]}

Murray, Matthew J. ^{[2
]}

Rodriguez-Galindo, Carlos ^{[3
,4
]}

Nicholson, James C. ^{[2
]}

Billmore, Deborah F. ^{[5
]}

Krailo, Mark D. ^{[6
]}

Dang, Ha M. ^{[6
]}

Amatruda, James F. ^{[7
,8
]}

Thornton, Claire M. ^{[10
]}

Arul, G. Suren ^{[11
]}

Stoneham, Sara J. ^{[12
]}

Pashankar, Farzana ^{[13
]}

Stark, Daniel ^{[14
]}

Shaikh, Furqan ^{[15
]}

Gershenson, David M. ^{[9
]}

Covens, Allan ^{[16
]}

Hurteau, Jean ^{[17
]}

Stenning, Sally P. ^{[18
]}

Feldman, Darren R. ^{[19
]}

Grimison, Peter S. ^{[20
]}

Huddart, Robert A. ^{[21
,22
]}

Sweeney, Christopher ^{[4
]}

Powles, Thomas ^{[23
]}

Lopes, Luiz Fernando ^{[24
]}

Agular, Simone dos Santos ^{[25
]}

Chinnaswamy, Girish ^{[26
]}

Khaleel, Sahar ^{[27
]}

Abouelnaga, Sherif ^{[27
]}

Hale, Juliet P. ^{[28
]}

Frazier, A. Lindsay ^{[3
,4
]}

机构：

[1] Emory Univ, Atlanta, GA 30322 USA

[2] Cambridge Univ Hosp Natl Hlth Serv NHS Fdn Trust, Cambridge, England

[3] Boston Childrens Hosp, Boston, MA USA

[4] Dana Farber Canc Inst, Boston, MA 02115 USA

[5] Riley Hosp Sick Children, Indianapolis, IN USA

[6] Univ So Calif, Los Angeles, CA USA

[7] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[8] Childrens Med Ctr, Dallas, TX 75235 USA

[9] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[10] Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland

[11] Birmingham Childrens Hosp NHS Fdn Trust, Birmingham, W Midlands, England

[12] Univ Coll London Hosp NHS Fdn Trust, London, England

[13] Yale Univ, Sch Med, New Haven, CT USA

[14] Univ Leeds, Leeds, W Yorkshire, England

[15] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[16] Univ Toronto, Toronto, ON, Canada

[17] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[18] MRC, London, England

[19] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[20] Sydney Canc Ctr, Sydney, NSW, Australia

[21] Inst Canc Res, Surrey, England

[22] Royal Marsden Hosp, Surrey, England

[23] Barts Canc Inst, London, England

[24] Barretos Pediat Canc Ctr, Sao Paulo, Brazil

[25] Ctr Infantil Boldrini, Campinas, SP, Brazil

[26] Tata Mem Hosp, Bombay 400012, Maharashtra, India

[27] Childrens Canc Hosp, Cairo, Egypt

[28] Royal Victoria Infirm NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 27期

基金：

英国医学研究理事会;

关键词：

HIGH-DOSE CHEMOTHERAPY; INTENSIVE INDUCTION CHEMOTHERAPY; COUNCIL EUROPEAN ORGANIZATION; RANDOMIZED PHASE-III; STAGE-I; UNITED-KINGDOM; COMBINATION CHEMOTHERAPY; YOUNG-ADULTS; STANDARD BEP; CISPLATIN;

D O I：

10.1200/JCO.2014.60.5337

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the past 35 years, survival rates for children with extracranial malignant germ cell tumors (GCTs) have increased significantly. Success has been achieved primarily through the application of platinum-based chemotherapy regimens; however, clinical challenges in GCTs remain. Excellent outcomes are not distributed uniformly across the heterogeneous distribution of age, histologic features, and primary tumor site. Despite good outcomes overall, the likelihood of a cure for certain sites and histologic conditions is less than 50%. In addition, there are considerable long-term treatment-related effects for survivors. Even modest cisplatin dosing can cause significant long-term morbidities. A particular challenge in designing new therapies for GCT is that a variety of specialists use different risk stratifications, staging systems, and treatment approaches for three distinct age groups (childhood, adolescence, and young adulthood). Traditionally, pediatric cancer patients younger than 15 years have been treated by pediatric oncologists in collaboration with their surgical specialty colleagues. Adolescents and young adults with GCTs often are treated by medical oncologists, urologists, or gynecologic oncologists. The therapeutic dilemma for all is how to best define disease risk so that therapy and toxicity can be appropriately reduced for some patients and intensified for others. Further clinical and biologic insights can only be achieved through collaborations that do not set limitations by age, sex, and primary tumor site. Therefore, international collaborations, spanning different cooperative groups and disciplines, have been developed to address these challenges. (C) 2015 by American Society of Clinical Oncology

引用

页码：3018 / U119

页数：14

共 67 条

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