WNK kinases and blood pressure control

被引：15
作者：
Deaton, Staci L. [1 ]
Sengupta, Samarpita [1 ]
Cobb, Melanie H. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
来源：
CURRENT HYPERTENSION REPORTS | 2009年 / 11卷 / 06期
关键词：
NA-CL COTRANSPORTER; PROTEIN-KINASE; SURFACE EXPRESSION; MOLECULAR PATHOGENESIS; INHERITED HYPERTENSION; MUTANT WNK4; IN-VIVO; CHANNEL; CELLS; OSR1;
D O I：
10.1007/s11906-009-0072-z
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The WNK (With No K-Lysine) family of proteins is widely expressed and has been shown to promote blood pressure homeostasis through a variety of mechanisms. Members of this family have been reported to affect sodium/chloride cotransporters, sodium/potassium/chloride cotransporters, potassium/chloride cotransporters, the renal outer medullary potassium channel, and the epithelial sodium channel, directly and indirectly. Mutations in WNK1 and WNK4 were shown to cause pseudohypoaldosteronism type II, a Mendelian disorder characterized by hypertension, hyperkalemia, and acidosis. Because of the complexity of the renal system, it has been difficult to completely define the role of these kinases in kidney function. This article reviews current knowledge of the role of these proteins in ion homeostasis and volume control.
引用
收藏
页码：421 / 426
页数：6
相关论文
共 50 条
  • [21] Kidney ion handling genes and their interaction in blood pressure control
    An, Caiyan
    Yang, Liuyi
    Han, Tengfei
    Song, Huazhong
    Li, Zichao
    Zhang, Junjing
    Zhang, Kejin
    BIOSCIENCE REPORTS, 2022, 42 (11)
  • [22] WNK kinases sense molecular crowding and rescue cell volume via phase separation
    Boyd-Shiwarski, Cary R.
    Shiwarski, Daniel J.
    Griffiths, Shawn E.
    Beacham, Rebecca T.
    Norrell, Logan
    Morrison, Daryl E.
    Wang, Jun
    Mann, Jacob
    Tennant, William
    Anderson, Eric N.
    Franks, Jonathan
    Calderon, Michael
    Connolly, Kelly A.
    Cheema, Muhammad Umar
    Weaver, Claire J.
    Nkashama, Lubika J.
    Weckerly, Claire C.
    Querry, Katherine E.
    Pandey, Udai Bhan
    Donnelly, Christopher J.
    Sun, Dandan
    Rodan, Aylin R.
    Subramanya, Arohan R.
    CELL, 2022, 185 (24) : 4488 - +
  • [23] The interplay of renal potassium and sodium handling in blood pressure regulation: critical role of the WNK-SPAK-NCC pathway
    Wu, Aihua
    Wolley, Martin
    Stowasser, Michael
    JOURNAL OF HUMAN HYPERTENSION, 2019, 33 (07) : 508 - 523
  • [24] Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms
    Nakamichi, N
    Murakami-Kojima, M
    Sato, E
    Kishi, Y
    Yamashino, T
    Mizuno, T
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (11) : 2429 - 2436
  • [25] Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases
    Kahle, Kristopher T.
    Rinehart, Jesse
    Lifton, Richard P.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (12): : 1150 - 1158
  • [26] Inorganic nitrate and nitrite and control of blood pressure
    Gilchrist, Mark
    Shore, Angela C.
    Benjamin, Nigel
    CARDIOVASCULAR RESEARCH, 2011, 89 (03) : 492 - 498
  • [27] Potassium Homeostasis and WNK Kinases in the Regulation of the Sodium-Chloride Cotransporter: Hyperaldosteronism and Its Metabolic Consequences
    Johnston, Jermaine G.
    Wingo, Charles S.
    KIDNEY360, 2022, 3 (11): : 1823 - 1828
  • [28] The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney
    Anderegg, Manuel A.
    Albano, Giuseppe
    Hanke, Daniela
    Deisl, Christine
    Uehlinger, Dominik E.
    Brandt, Simone
    Bhardwaj, Rajesh
    Hediger, Matthias A.
    Fuster, Daniel G.
    KIDNEY INTERNATIONAL, 2021, 99 (02) : 350 - 363
  • [29] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure
    Ohta, Akihito
    Rai, Tatemitsu
    Yui, Naofumi
    Chiga, Motoko
    Yang, Sung-Sen
    Lin, Shih-Hua
    Sohara, Eisei
    Sasaki, Sei
    Uchida, Shinichi
    HUMAN MOLECULAR GENETICS, 2009, 18 (20) : 3978 - 3986
  • [30] Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension
    Zhang, Chong
    Meermeier, Nicholas P.
    Terker, Andrew S.
    Blankenstein, Katharina I.
    Singer, Jeffrey D.
    Hadchouel, Juliette
    Ellison, David H.
    Yang, Chao-Ling
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (01) : 44 - 48
12345