REMIFENTANIL DOES NOT AFFECT HUMAN MICROGLIAL IMMUNE ACTIVATION IN RESPONSE TO PRO-INFLAMMATORY CYTOKINES

被引：4

作者：

Dello Russo, Cinzia ^{[1
,2
]}

Cappoli, Natalia ^{[1
,6
]}

Tabolacci, Elisabetta ^{[3
]}

Sollazzi, Liliana ^{[4
,5
]}

Navarra, Pierluigi ^{[1
]}

Aceto, Paola ^{[4
,5
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet, Sez Farmacol, Rome, Italy

[2] Univ Liverpool, Inst Syst Mol & Integrat Biol ISMIB, Dept Pharmacol & Therapeut, Liverpool, England

[3] Fdn Policlin Univ A Gemelli IRCCS, Univ Cattolica Sacro Cuore, Dipartimento Sci V & San Pubbl, Sez Med Genomica, Rome, Italy

[4] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Emergenza, Anestesiolog & Rianimaz, Rome, Italy

[5] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnolog Base, Clin Intensivolog & Perioperatorie, Rome, Italy

[6] Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet Sez Farmacol, Lgo Vito 1, I-00168 Rome, Italy

来源：

EXCLI JOURNAL | 2022年 / 22卷

关键词：

Human microglia; remifentanil; hyperalgesia; interleukin-6; interleukin-8; monocyte chemotactic pro-tein 1; OPIOID-INDUCED HYPERALGESIA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED POSTOPERATIVE HYPERALGESIA; RECEPTOR FUNCTION; PHOSPHORYLATION; RECRUITMENT; EXPRESSION; CHEMOKINES; TOLERANCE; MECHANISM;

D O I：

10.17179/excli2022-5667

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Remifentanil is a potent ultra-short acting mu-opioid analgesic drug, frequently used in anaesthesia due to its favor-able pharmacodynamic and pharmacokinetic profile. It may be associated with the occurrence of hyperalgesia. Preclinical studies suggest a potential role of microglia, although the molecular mechanisms have not been fully elucidated. Considering the role of microglia in brain inflammation and the relevant differences among species, the effects of remifentanil were studied on the human microglial C20 cells. The drug was tested at clinically relevant concentrations under basal and inflammatory conditions. In the C20 cells, the expression and secretion of interleukin 6, interleukin 8 and the monocyte chemotactic protein 1 were rapidly induced by a mixture of pro -inflammatory cytokines. This stimulatory effect was sustained up to 24 h. Remifentanil did not exert any toxic effect nor modify the production of these inflammatory mediators, thus suggesting the lack of direct immune modulatory actions on human microglia.

引用

页码：295 / 309

页数：15

共 44 条

[1] Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 [J].