Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells

被引：19
作者：
Guo, Erkun [1 ]
Liu, Hongjiang [1 ]
Liu, Xiaopeng [1 ]
机构：
[1] Hebei Med Univ, Hosp 2, Dept Neurosurg, 215 West Heping Rd, Shijiazhuang 050000, Hebei, Peoples R China
来源：
ONCOLOGY RESEARCH | 2017年 / 25卷 / 03期
关键词：
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2); Proliferation; Migration; Invasion; Glioma; FACTOR-RELATED GENE; SONIC-HEDGEHOG; GROWTH; EXPRESSION; PATHWAY; SURFACE; PROGNOSIS; TARGET;
D O I：
10.3727/096504016X14747335734344
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed glioma cell migration and invasion in vitro. Furthermore, we found that the Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. In light of the results obtained from our study, SCUBE2 may be regarded as a potential therapeutic target for glioma.
引用
收藏
页码：437 / 444
页数：8
相关论文
共 35 条
[1]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[2]   Nuclear EGFR as a molecular target in cancer [J].
Brand, Toni M. ;
Iida, Mari ;
Luthar, Neha ;
Starr, Megan M. ;
Huppert, Evan J. ;
Wheeler, Deric L. .
RADIOTHERAPY AND ONCOLOGY, 2013, 108 (03) :370-377
[3]   SCUBE2 Suppresses Breast Tumor Cell Proliferation and Confers a Favorable Prognosis in Invasive Breast Cancer [J].
Cheng, Chien-Jui ;
Lin, Yuh-Charn ;
Tsai, Ming-Tzu ;
Chen, Ching-Shyang ;
Hsieh, Mao-Chih ;
Chen, Chi-Long ;
Yang, Ruey-Bing .
CANCER RESEARCH, 2009, 69 (08) :3634-3641
[4]   HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity [J].
Clement, Virginie ;
Sanchez, Pilar ;
de Tribolet, Nicolas ;
Radovanovic, Ivan ;
Altaba, Ariel Ruiz I. .
CURRENT BIOLOGY, 2007, 17 (02) :165-172
[5]  
Dahmane N, 2001, DEVELOPMENT, V128, P5201
[6]   Hedgehog signalling in cancer formation and maintenance [J].
di Magliano, MP ;
Hebrok, M .
NATURE REVIEWS CANCER, 2003, 3 (12) :903-911
[7]   SONIC-HEDGEHOG, A MEMBER OF A FAMILY OF PUTATIVE SIGNALING MOLECULES, IS IMPLICATED IN THE REGULATION OF CNS POLARITY [J].
ECHELARD, Y ;
EPSTEIN, DJ ;
STJACQUES, B ;
SHEN, L ;
MOHLER, J ;
MCMAHON, JA ;
MCMAHON, AP .
CELL, 1993, 75 (07) :1417-1430
[8]   Hedgehog signaling promotes prostate xenograft tumor growth [J].
Fan, L ;
Pepicelli, CV ;
Dibble, CC ;
Catbagan, W ;
Zarycki, JL ;
Laciak, R ;
Gipp, J ;
Shaw, A ;
Lamm, MLG ;
Munoz, A ;
Lipinski, R ;
Thrasher, JB ;
Bushman, W .
ENDOCRINOLOGY, 2004, 145 (08) :3961-3970
[9]   Genetics of adult glioma [J].
Goodenberger, McKinsey L. ;
Jenkins, Robert B. .
CANCER GENETICS, 2012, 205 (12) :613-621
[10]   Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1) [J].
Grimmond, S ;
Larder, R ;
Van Hateren, N ;
Siggers, P ;
Hulsebos, TJM ;
Arkell, R ;
Greenfield, A .
GENOMICS, 2000, 70 (01) :74-81
1234