No association between p73 G4C14-to-A4T14 polymorphism and the risk of lung cancer in a Korean population

被引:25
作者
Choi, Jin Eun
Kang, Hyo Gyoung
Chae, Myung Hwa
Kim, Eun Jin
Lee, Won Kee
Cha, Sung Ick
Kim, Chang Ho
Jung, Tae Hoon
Park, Jae Yong [1 ]
机构
[1] Kyungpook Natl Univ Hosp, Inst Canc Res, Taegu 700412, South Korea
[2] Kyungpook Natl Univ Hosp, Dept Internal Med, Taegu 700412, South Korea
[3] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Taegu 700412, South Korea
关键词
p73; polymorphism; lung cancer; genetic susceptibility;
D O I
10.1007/s10528-006-9056-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A member of the p53 family, p73 may play an important role in the development of lung cancer. Variations in the DNA sequence in the p73 gene can lead to alterations in the production of p73 and/or activity, which can affect an individual's susceptibility to lung cancer. To test this hypothesis, this study examined the association between the G4C14-to-A4T14 polymorphism in the p73 gene and the risk of lung cancer in a Korean population. The p73 G4C14-to-A4T14 genotypes were determined in 582 lung cancer patients and 582 healthy age- and gender-matched control subjects. Compared with the GC/GC genotype, the GC/AT and the AT/AT genotypes were not significantly associated with the risk of lung cancer [adjusted odds ratio (OR) = 1.08, 95% confidence interval (CI) = 0.84-1.38; and adjusted OR = 1.37, 95% CI = 0.83-2.24, respectively]. In addition, the risk estimate for the combined variant genotype (GC/AT + AT/AT) was similar to that of the GC/GC genotype (a dominant model for the AT allele, adjusted OR = 1.12, 95% CI = 0.88-1.41). These results suggest that the p73 G4C14-to-A4T14 polymorphism does not significantly affect susceptibility to lung cancer in the Korean population.
引用
收藏
页码:543 / 550
页数:8
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