Effectiveness comparisons of Chinese patent medicine on insomnia A protocol for systematic review and Bayesian network meta-analysis

Background: In recent years, the incidence of insomnia is increasing. However, the existing therapy methods for cannot fundamentally treat the disease. Meanwhile, Chinese patent medicine (CPM) plays an active role in the treatment of insomnia. However, there is no comparison and ranking of the efficacy of every CPM. Therefore, our study will use network meta-analysis to compare the efficacy of different CPM on insomnia, in order to provide evidence-based medical evidence for clinical treatment. Methods: We will search CNKI, Wanfang, VIP, CBM, Pubmed, Cochrane Library, Embase for the randomized controlled trials of CPM in the treatment of insomnia (up to December 31, 2020). We will use RevMan5.3, Stata15.1 and ADDIS software for statistical analysis. We will draw the surface under cumulative ranking area to predict the order of efficacy. Results: We aim to rank the efficacy and safety of different CPM for the treatment of insomnia. Conclusion: CPM plays a positive role in the treatment of insomnia and can provide evidence support for clinicians and patients INPLASY registration number: INPLASY2020120121