Fungicidal properties of meso-arylglycosylporphyrins:: influence of sugar substituents on photoinduced damage in the yeast Saccharomyces cerevisiae

被引：49

作者：

Carré, V

Gaud, O

Sylvain, I

Bourdon, O

Spiro, M

Blais, J

Granet, R

Krausz, P

Guilloton, M

机构：

[1] Univ Limoges, Fac Sci, Inst Biotechnol, F-87060 Limoges, France

[2] Univ Limoges, Fac Sci, Lab Chim Subst Nat, F-87060 Limoges, France

[3] Univ Paris 06, Lab Physicochim Biomol & Cellulaire, F-75242 Paris, France

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1999年 / 48卷 / 01期

关键词：

fungicides; photoinduced damage; porphyrins; yeasts; carbohydrates; photodynamic therapy;

D O I：

10.1016/S1011-1344(99)00009-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of neutral meso-arylglycosylporphyrins has been tested in order to evaluate their potency as antifungal agents against the yeast Saccharomyces cerevisiae. Photodynamic activity of these molecules results in intracellular damage as evidenced by the loss of clonogenicity and DNA fragmentation. The ability of these photosensitizers to permeate yeast cells is determined by microspectrofluorimetry and is correlated with their antifungal potency. Amphiphilic porphyrin derivatives are shown to exhibit the more pronounced photoactivity. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：57 / 62

页数：6

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