Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

被引：332

作者：

Tan, Tze Guan ^{[1
]}

Sefik, Esen ^{[1
]}

Geva-Zatorsky, Naama ^{[1
]}

Kua, Lindsay ^{[1
]}

Naskar, Debdut ^{[2
]}

Teng, Fei ^{[2
]}

Pasman, Lesley ^{[1
]}

Ortiz-Lopez, Adriana ^{[1
]}

Jupp, Ray ^{[3
]}

Wu, Hsin-Jung Joyce ^{[2
,4
]}

Kasper, Dennis L. ^{[1
]}

Benoist, Christophe ^{[1
]}

Mathis, Diane ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

[2] Univ Arizona, Dept Immunobiol, Tucson, AZ 85719 USA

[3] UCB Pharma, Slough SL1 3WE, Berks, England

[4] Univ Arizona, Coll Med, Arizona Arthrit Ctr, Tucson, AZ 85719 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2016年 / 113卷 / 50期

基金：

美国国家科学基金会;

关键词：

microbiota; Th17; cells; probiotic; mucosal immunology; intestine; SEGMENTED FILAMENTOUS BACTERIA; GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; TYPE-2; IMMUNITY; HELPER-CELLS; T(H)17 CELLS; MICROBIOTA; INTERLEUKIN-17; INNATE;

D O I：

10.1073/pnas.1617460113

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here, we identified human symbiont bacterial species, in particular Bifidobacterium adolescentis, that could, alone, induce Th17 cells in the murine intestine. Similar to SFB, B. adolescentis was closely associated with the gut epithelium and engendered cognate Th17 cells without attendant inflammation. However, B. adolescentis elicited a transcriptional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th17 cell accumulation. Inoculation of mice with B. adolescentis exacerbated autoimmune arthritis in the K/BxN mouse model. Several off-theshelf probiotic preparations that include Bifidobacterium strains also drove intestinal Th17 cell accumulation.

引用

页码：E8141 / E8150

页数：10

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