Physiological roles of connexins and pannexins in reproductive organs

被引：18

作者：

Kibschull, Mark ^{[1
]}

Gellhaus, Alexandra ^{[2
]}

Carette, Diane ^{[3
,4
,5
]}

Segretain, Dominique ^{[3
,4
]}

Pointis, Georges ^{[5
]}

Gilleron, Jerome ^{[5
]}

机构：

[1] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5T 3H7, Canada

[2] Univ Duisburg Essen, Dept Gynecol & Obstet, D-45122 Essen, Germany

[3] Univ Paris 05, UMR S1147, F-75006 Paris, France

[4] Univ Versailles, F-78035 St Quentin en Yvelines, France

[5] Univ Nice Sophia Antipolis, INSERM, U1065, F-06204 Nice 3, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 15期

关键词：

Connexin; Pannexin; Testis; Ovary; Function; GAP-JUNCTIONAL COMMUNICATION; SMOOTH-MUSCLE-CELLS; NEONATAL MICE LACKING; BLOOD-TESTIS BARRIER; INTERCELLULAR COMMUNICATION; GERM-CELL; PREIMPLANTATION DEVELOPMENT; GENE-EXPRESSION; SERTOLI-CELLS; IN-VITRO;

D O I：

10.1007/s00018-015-1965-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reproductive organs are complex and well-structured tissues essential to perpetuate the species. In mammals, the male and female reproductive organs vary on their organization, morphology and function. Connectivity between cells in such tissues plays pivotal roles in organogenesis and tissue functions through the regulation of cellular proliferation, migration, differentiation and apoptosis. Connexins and pannexins can be seen as major regulators of these physiological processes. In the present review, we assembled several lines of evidence demonstrating that these two families of proteins are essential for male and female reproduction.

引用

页码：2879 / 2898

页数：20

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