The Geometric Structure of the Brain Fiber Pathways

被引：328

作者：

Wedeen, Van J. ^{[1
,2
]}

Rosene, Douglas L. ^{[3
]}

Wang, Ruopeng ^{[1
,2
]}

Dai, Guangping ^{[1
,2
]}

Mortazavi, Farzad ^{[3
]}

Hagmann, Patric ^{[4
]}

Kaas, Jon H. ^{[5
]}

Tseng, Wen-Yih I. ^{[6
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp MGH, Dept Radiol, Charlestown, MA 02129 USA

[2] MGH Massachussetts Inst Technol, Athinoula Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[3] Boston Univ, Dept Anat & Neurobiol, Boston, MA 02118 USA

[4] Univ Lausanne, Univ Hosp Ctr, Dept Radiol, CH-1011 Lausanne, Switzerland

[5] Vanderbilt Univ, Coll Arts & Sci, Dept Psychol, Nashville, TN 37240 USA

[6] Natl Taiwan Univ, Coll Med, Dept Radiol, Ctr Optoelect Biomed, Taipei 100, Taiwan

来源：

SCIENCE | 2012年 / 335卷 / 6076期

基金：

美国国家科学基金会;

关键词：

NERVOUS-SYSTEM; TRACTOGRAPHY; ARCHITECTURE; CORTEX; MRI;

D O I：

10.1126/science.1215280

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The structure of the brain as a product of morphogenesis is difficult to reconcile with the observed complexity of cerebral connectivity. We therefore analyzed relationships of adjacency and crossing between cerebral fiber pathways in four nonhuman primate species and in humans by using diffusion magnetic resonance imaging. The cerebral fiber pathways formed a rectilinear three-dimensional grid continuous with the three principal axes of development. Cortico-cortical pathways formed parallel sheets of interwoven paths in the longitudinal and medio-lateral axes, in which major pathways were local condensations. Cross-species homology was strong and showed emergence of complex gyral connectivity by continuous elaboration of this grid structure. This architecture naturally supports functional spatio-temporal coherence, developmental path-finding, and incremental rewiring with correlated adaptation of structure and function in cerebral plasticity and evolution.

引用

页码：1628 / 1634

页数：7

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