Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

被引：6

作者：

Chen Shu ^{[1
,2
]}

Zhang Yan-Yan ^{[3
]}

Zhang Hai ^{[2
]}

Ding Long-Kun ^{[4
]}

Xi Yue ^{[4
]}

Yan Man ^{[4
]}

Sun Chang ^{[4
]}

Wu Liang ^{[4
]}

Hu Hao ^{[1
]}

机构：

[1] Soochow Univ, Gen Surg Dept, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

[2] Jiangsu Univ, Gen Surg Dept, Affiliated Hosp, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China

[3] Yangzhou Univ, Testing Ctr, Wenhui Rd 48, Yangzhou 225009, Jiangsu, Peoples R China

[4] Jiangsu Univ, Sch Med, Xuefu Rd 301, Zhenjiang 212013, Jiangsu, Peoples R China

来源：

ACTA PHARMACEUTICA | 2022年 / 72卷 / 04期

关键词：

short-chain fatty acids (SCFAs); autophagy; NLRP3; nuclear factor-kappa B (NF-kappa B); inflammation; CHAIN FATTY-ACIDS; ACUTE LUNG INJURY; NLRP3; INFLAMMASOME; AUTOPHAGY; INHIBITION; ACTIVATION; APOPTOSIS;

D O I：

10.2478/acph-2022-0036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three main SCFAs could inhibit A. baumannii-stimulated THP-1 cell NF-kappa B pathway activity and the expressions of NLRP3 inflammasome and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and MR-2 expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed IL-1 beta and IFN-gamma expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by A. baumannii, and the inhibitory effect was in the order of NaB> NaPc> NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-kappa B/ROS/NLRP3 signaling pathway.

引用

页码：615 / 628

页数：14