Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

被引：5
|
作者：
Chen Shu [1 ,2 ]
Zhang Yan-Yan [3 ]
Zhang Hai [2 ]
Ding Long-Kun [4 ]
Xi Yue [4 ]
Yan Man [4 ]
Sun Chang [4 ]
Wu Liang [4 ]
Hu Hao [1 ]
机构：
[1] Soochow Univ, Gen Surg Dept, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China
[2] Jiangsu Univ, Gen Surg Dept, Affiliated Hosp, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
[3] Yangzhou Univ, Testing Ctr, Wenhui Rd 48, Yangzhou 225009, Jiangsu, Peoples R China
[4] Jiangsu Univ, Sch Med, Xuefu Rd 301, Zhenjiang 212013, Jiangsu, Peoples R China
来源：
ACTA PHARMACEUTICA | 2022年 / 72卷 / 04期
关键词：
short-chain fatty acids (SCFAs); autophagy; NLRP3; nuclear factor-kappa B (NF-kappa B); inflammation; CHAIN FATTY-ACIDS; ACUTE LUNG INJURY; NLRP3; INFLAMMASOME; AUTOPHAGY; INHIBITION; ACTIVATION; APOPTOSIS;
D O I：
10.2478/acph-2022-0036
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three main SCFAs could inhibit A. baumannii-stimulated THP-1 cell NF-kappa B pathway activity and the expressions of NLRP3 inflammasome and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and MR-2 expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed IL-1 beta and IFN-gamma expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by A. baumannii, and the inhibitory effect was in the order of NaB> NaPc> NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-kappa B/ROS/NLRP3 signaling pathway.
引用
收藏
页码：615 / 628
页数：14
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