Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development

被引：88

作者：

Anahi Valdes-Rives, Silvia ^{[1
]}

Gonzalez-Arenas, Aliesha ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Ciudad Univ, Ciudad De Mexico 04510, Mexico

来源：

MEDIATORS OF INFLAMMATION | 2017年 / 2017卷

关键词：

PROTEIN-COUPLED RECEPTOR; KINASE-C-DELTA; NF-KAPPA-B; OVARIAN-CANCER; LYSOPHOSPHOLIPASE-D; MOLECULAR-CLONING; LPA RECEPTORS; EDG FAMILY; INTERLEUKIN-8; SECRETION; SPHINGOSINE; 1-PHOSPHATE;

D O I：

10.1155/2017/9173090

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA(1-6), to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression.

引用

页数：15

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