Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development

被引：88
作者：
Anahi Valdes-Rives, Silvia [1 ]
Gonzalez-Arenas, Aliesha [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Ciudad Univ, Ciudad De Mexico 04510, Mexico
来源：
MEDIATORS OF INFLAMMATION | 2017年 / 2017卷
关键词：
PROTEIN-COUPLED RECEPTOR; KINASE-C-DELTA; NF-KAPPA-B; OVARIAN-CANCER; LYSOPHOSPHOLIPASE-D; MOLECULAR-CLONING; LPA RECEPTORS; EDG FAMILY; INTERLEUKIN-8; SECRETION; SPHINGOSINE; 1-PHOSPHATE;
D O I：
10.1155/2017/9173090
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA(1-6), to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression.
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页数：15
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共 142 条
[1]   Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer [J].
Al Murri, AM ;
Bartlett, JMS ;
Canney, PA ;
Doughty, JC ;
Wilson, C ;
McMillan, DC .
BRITISH JOURNAL OF CANCER, 2006, 94 (02) :227-230
[2]   Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation [J].
Albers, Harald M. H. G. ;
Dong, Anping ;
van Meeteren, Laurens A. ;
Egan, David A. ;
Sunkara, Manjula ;
van Tilburg, Erica W. ;
Schuurman, Karianne ;
van Tellingen, Olaf ;
Morris, Andrew J. ;
Smyth, Susan S. ;
Moolenaar, Wouter H. ;
Ovaa, Huib .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7257-7262
[3]   Gene expression profiling for the identification of G-protein coupled receptors in human platelets [J].
Amisten, Stefan ;
Braun, Oscar Oe ;
Bengtsson, Anders ;
Erlinge, David .
THROMBOSIS RESEARCH, 2008, 122 (01) :47-57
[4]   Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [J].
An, SZ ;
Bleu, T ;
Hallmark, OG ;
Goetzl, EJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :7906-7910
[5]   Two pathways for lysophosphatidic acid production [J].
Aoki, Junken ;
Inoue, Asuka ;
Okudaira, Shinichi .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2008, 1781 (09) :513-518
[6]   Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells [J].
Araki, Mutsumi ;
Kitayoshi, Misaho ;
Dong, Yan ;
Hirane, Miku ;
Ozaki, Shuhei ;
Mori, Shiori ;
Fukushima, Nobuyuki ;
Honoki, Kanya ;
Tsujiuchi, Toshifumi .
GROWTH FACTORS, 2014, 32 (3-4) :117-122
[7]   Inflammation and lung cancer: Roles of reactive oxygen/nitrogen species [J].
Azad, Neelam ;
Rojanasakul, Yon ;
Vallyathan, Val .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 2008, 11 (01) :1-15
[8]   Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis [J].
Bai, Zhongbin ;
Cai, Linjun ;
Umemoto, Eiji ;
Takeda, Akira ;
Tohya, Kazuo ;
Komai, Yutaka ;
Veeraveedu, Punniyakoti Thanikachalam ;
Hata, Erina ;
Sugiura, Yuki ;
Kubo, Akiko ;
Suematsu, Makoto ;
Hayasaka, Haruko ;
Okudaira, Shinichi ;
Aoki, Junken ;
Tanaka, Toshiyuki ;
Albers, Harald M. H. G. ;
Ovaa, Huib ;
Miyasaka, Masayuki .
JOURNAL OF IMMUNOLOGY, 2013, 190 (05) :2036-2048
[9]   Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry [J].
Baker, DL ;
Desiderio, DM ;
Miller, DD ;
Tolley, B ;
Tigyi, GJ .
ANALYTICAL BIOCHEMISTRY, 2001, 292 (02) :287-295
[10]   Inflammation and cancer: back to Virchow? [J].
Balkwill, F ;
Mantovani, A .
LANCET, 2001, 357 (9255) :539-545
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