Complement and its breakdown products in SLE

被引：51

作者：

Sturfelt, G ^{[1
]}

Truedsson, L

机构：

[1] Univ Lund Hosp, Dept Rheumatol, SE-22185 Lund, Sweden

[2] Univ Lund Hosp, Dept Clin Microbiol & Immunol, S-22185 Lund, Sweden

来源：

RHEUMATOLOGY | 2005年 / 44卷 / 10期

关键词：

complement; SLE;

D O I：

10.1093/rheumatology/keh719

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The complement system has important protective functions in both the innate and the adaptive immune systems but can also, when inappropriately activated, cause tissue damage. Complement deficiency predisposes to infection and also to development of autoimmune disease, especially SLE, and complement is at the same time involved in the pathogenesis of this disease. In this review, various aspects of this dualism are discussed. An overview of activation pathways and activation products is given, together with a description of autoimmunity against complement and the potential of complement regulation in future therapeutics.

引用

页码：1227 / 1232

页数：6

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