The Association Between GC Gene Polymorphisms and Metabolic Syndrome in Chinese Rural Population: A Case-Control Study

被引:8
作者
Zhao, Tong [1 ]
Zhang, Dongdong [1 ]
Liu, Yiming [1 ]
Feng, Mingming [1 ]
Xu, Ze [1 ]
Huang, Haoyue [1 ]
Zhang, Luoya [1 ]
Li, Wenjie [1 ]
Li, Xing [1 ]
机构
[1] Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
GC; polymorphism; metabolic syndrome; rural population; VITAMIN-D-BINDING; DENSITY-LIPOPROTEIN CHOLESTEROL; PROTEIN-LEVELS; PLASMA; HYPERTENSION; DISEASE; IMPACT; RISK;
D O I
10.2147/DMSO.S346528
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: GC (group-specific component globulin) encoding VDBP (Vitamin D binding protein) polymorphisms have been associated with susceptibility to some diseases such as diabetes, obesity, osteoporosis, and polycystic ovary syndrome, but the evidence for metabolic syndrome (MetS) in the Chinese rural population is inconclusive. Therefore, we investigated the relationship between GC variants (rs7041, rs4588, rs2282679, and rs705117) and MetS risk as well as VDBP levels in the Chinese rural population. Patients and Methods: The participants (range of age: 20-90 years) of this case-control study were recruited from the northern Chinese Han rural population. We matched 445 MetS cases with non-MetS controls in a 1:1 ratio by sex, age (within 5 years). Real-time PCR technology was carried out by TaqMan assays to examine the four variants of rs7041, rs4588, rs2282679, and rs705117 within the GC gene. To identify the association of GC gene polymorphisms with MetS, we calculated ORs using a conditional logistic regression model adjusted for potential confounding factors. Results: We observed inverse associations of CA and AA genotypes of rs4588 with risk of MetS (OR = 0.678, 95% CI 0.505-0.910, P = 0.010; 0.603, 95% CI 0.373-0.973, P = 0.039, respectively) compared with carriers of CC genotype. A similar relationship was also found between rs2282679 and MetS, showing that carrying AC genotype of rs2282679 can decrease the risk of MetS (OR = 0.683, 95% CI 0.509-0.917, P = 0.011) compared with carriers of AA genotype. The results of correlation analysis between MetS components and GC polymorphisms showed that the ORs of AA genotype of rs4588 with high level of TG (triglycerides) and low level of HDL-C (high-density lipoprotein cholesterol) were 0.473 (95% CI 0.245-0.911, P = 0.025) and 0.268 (95% CI 0.117-0.615, P = 0.002), respectively; the ORs of CC genotype of rs2282679 with high level of TG and low level of HDL-C were 0.428 (95% CI 0.217-0.842, P = 0.014) and 0.263 (95% CI 0.110-0.628, P = 0.003), respectively. However, there was no significant association between the concentration of VDBP and MetS risk. Conclusion: Among the Chinese rural population, GC polymorphism was associated with lower metabolic syndrome susceptibility, which might be through affecting blood lipid levels (TG and HDL-C).
引用
收藏
页码:165 / 174
页数:10
相关论文
共 43 条
[1]   The metabolic syndrome - a new worldwide definition [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
LANCET, 2005, 366 (9491) :1059-1062
[2]   Independent associations of polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism [J].
Almesri, Norah ;
Das, Nagalla S. ;
Ali, Muhallab E. ;
Gumaa, Khalid ;
Giha, Hayder Ahmed .
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2016, 41 (04) :345-353
[3]  
Bagnasco NJT, 2015, DIABETOL METAB SYNDR, V7, DOI [10.1186/1758- 5996-7-s1-a223, DOI 10.1186/1758-5996-7-S1-A223]
[4]   Genetic and epigenetic factors influencing vitamin D status [J].
Bahrami, Afsane ;
Sadeghnia, Hamid Reza ;
Tabatabaeizadeh, Seyed-Amir ;
Bahrami-Taghanaki, Hamidreza ;
Behboodi, Negin ;
Esmaeili, Habibollah ;
Ferns, Gordon A. ;
Mobarhan, Majid Ghayour ;
Avan, Amir .
JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (05) :4033-4043
[5]   Splicing in action: assessing disease causing sequence changes [J].
Baralle, D ;
Baralle, M .
JOURNAL OF MEDICAL GENETICS, 2005, 42 (10) :737-748
[6]  
Blaton Victor, 2007, EJIFCC, V18, P15
[7]   Intra-abdominal fat is a major determinant of the national cholesterol education program adult treatment panel III criteria for the metabolic syndrome [J].
Carr, DB ;
Utzschneider, KM ;
Hull, RL ;
Kodama, K ;
Retzlaff, BM ;
Brunzell, JD ;
Shofer, JB ;
Fish, BE ;
Knopp, RH ;
Kahn, SE .
DIABETES, 2004, 53 (08) :2087-2094
[8]   Association between family history of diabetes and clusters of adherence to healthy behaviors: cross-sectional results from the Health Examinees-Gem (HFXA-G) study [J].
Choi, Jaesung ;
Choi, Ji-Yeob ;
Lee, Sang-Ah ;
Lee, Kyoung-Mu ;
Shin, Aesun ;
Oh, Juhwan ;
Park, JooYong ;
Song, Minkyo ;
Yang, Jae Jeong ;
Lee, Jong-koo ;
Kang, Daehee .
BMJ OPEN, 2019, 9 (06)
[9]   High Density Lipoproteins and Diabetes [J].
Cochran, Blake J. ;
Ong, Kwok-Leung ;
Manandhar, Bikash ;
Rye, Kerry-Anne .
CELLS, 2021, 10 (04)
[10]   The Metabolic Syndrome [J].
Cornier, Marc-Andre ;
Dabelea, Dana ;
Hernandez, Teri L. ;
Lindstrom, Rachel C. ;
Steig, Amy J. ;
Stob, Nicole R. ;
Van Pelt, Rachael E. ;
Wang, Hong ;
Eckel, Robert H. .
ENDOCRINE REVIEWS, 2008, 29 (07) :777-822