Antimicrobial Treatment on a Catheter-Related Bloodstream Infection (CRBSI) Case Due to Transition of a Multi-Drug-Resistant Ralstonia mannitolilytica from Commensal to Pathogen during Hospitalization

被引：5

作者：

Liu, Junyan ^{[1
,2
]}

Peters, Brian M. ^{[3
]}

Yang, Ling ^{[4
,5
]}

Yu, Hui ^{[4
]}

Feng, Donghua ^{[4
]}

Chen, Dingqiang ^{[4
,5
]}

Xu, Zhenbo ^{[6
,7
]}

机构：

[1] Zhongkai Univ Agr & Engn, Coll Light Ind & Food Sci, Innovat Res Inst Modern Agr Engn, Guangdong Prov Key Lab Sci & Technol Lingnan Spec, Guangzhou 510225, Peoples R China

[2] Zhongkai Univ Agr & Engn, Key Lab Green Proc & Intelligent Mfg Lingnan Spec, Guangzhou 510225, Peoples R China

[3] Univ Tennessee, Dept Clin Pharm & Translat Sci, Hlth Sci Ctr, Memphis, TN 38163 USA

[4] Guangzhou Med Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou 510120, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 1, Ctr Translat Med, Guangzhou 510120, Peoples R China

[6] South China Univ Technol, Engn Res Ctr Starch & Vegetable Prot Proc, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Sch Food Sci & Engn,Minist Educ, Guangzhou 510640, Peoples R China

[7] Shantou Univ, Dept Lab Med, Affiliated Hosp 2, Med Coll, Shantou 515041, Peoples R China

来源：

ANTIBIOTICS-BASEL | 2022年 / 11卷 / 10期

关键词：

Ralstonia mannitolilytica; chronic obstructive pulmonary disease (COPD); catheter-related bloodstream infection (CRBSI); commensal; pathogen; CYSTIC-FIBROSIS; OUTBREAK; BACTEREMIA; IDENTIFICATION; PICKETTII; COPD;

D O I：

10.3390/antibiotics11101376

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Despite its commonly overlooked role as a commensal, Ralstonia mannitolilytica becomes an emerging global opportunistic human pathogen and a causative agent of various infections and diseases. In respiratory illnesses, including cystic fibrosis and chronic obstructive pulmonary disease (COPD), R. mannitolilytica is also identified presumably as colonizer. In this study, one distinctive clone of R. mannitolilytica was firstly identified as colonizer for the first 20 days during hospitalization of a patient. It was then identified as a causative agent for catheter-related bloodstream infection with negative identification after effective treatment, verifying its transition from commensal to pathogen. In conclusion, we provide convincing evidence that during hospitalization of a patient, R. mannitolilytica transitioned from commensal to pathogen in the respiratory tract leading to catheter-related bloodstream infection (CRBSI).

引用

页数：8