Detailed 1H and 13C NMR structural assignment and relative stereochemistry determination for three closely related sesquiterpene lactones

被引：14

作者：

Gomes Heleno, Vladimir Constantino ^{[1
,2
]}

de Oliveira, Kleber Thiago ^{[3
]}

Callegari Lopes, Joio Luis ^{[4
]}

Lopes, Norberto Peporine ^{[4
]}

Ferreira, Antonio Gilberto ^{[2
]}

机构：

[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, BR-14404600 Franca, SP, Brazil

[2] Univ Fed Sao Carlos, Ctr Ciencias Exatas & Tecnol, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil

[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2008年 / 46卷 / 06期

关键词：

NMR; J-resolved; DPFGSE-NOE; stereochemistry; sesquiterpene lactones; furanoheliangolides; eremantholide C;

D O I：

10.1002/mrc.2220

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A complete analysis of H-1 and C-13 NMR spectra of the trypanocidal sesquiterpene lactone eremantholide C and two of its analogues is described. These structurally similar sesquiterpene lactones were submitted to H-1 NMR, C-13 (H-1) NMR, gCOSY, gHSQC, gHMBC, J-resolved and DPFGSE-NOE NMR techniques. The detailed analysis of those results, correlated to some computational calculations (molecular mechanics), led to the total and unequivocal assignment of all H-1 and C-13 NMR data. The determination of all H-1/H-1 coupling constants and all signal multiplicities, together with the elimination of previous ambiguities were also achieved. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：576 / 581

页数：6

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