HLA-A29 and Birdshot Chorioretinopathy

被引:56
作者
Brezin, Antoine P. [1 ]
Monnet, Dominique [1 ]
Cohen, Jacques H. M. [2 ,3 ]
Levinson, Ralph D. [4 ,5 ]
机构
[1] Univ Paris 05, Ctr Cochin Ambulatoire Ophtalmol, Fac Med, AP HP, F-75014 Paris, France
[2] Univ Reims, CHU Reims, Immunol Lab, Reims, France
[3] Univ Reims, Inst Fed Rech 53, EA 3798, Reims, France
[4] Univ Calif Los Angeles, Jules Stein Eye Inst, Ocular Inflammatory Dis Ctr, Los Angeles, CA 90024 USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90024 USA
关键词
birdshot chorioretinopathy; HLA; HLA-A29; allele; transgenic models; TRANSGENIC MICE; RETINOCHOROIDOPATHY; RETINOPATHY; UVEITIS; ANTIGEN; INDIVIDUALS; SUBTYPES;
D O I
10.3109/09273948.2011.619295
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Birdshot chorioretinopathy primarily affects patients of European descent. At least 96%, if not all patients, are HLA-A29 carriers. HLA-A*29:01 and HLA-A*29:02, the two main subtypes of HLA-A29, differ only by a single mutation. In the general population HLA-A*29:02 is most frequent in whites, while HLA-A*29:01 is more frequent in Asians. The differential distribution of HLA-A*29:01 and HLA-A*29:02 has been actively debated as an explanation for the selective development of the disease in patients of European descent, but is no longer a valid argument. Another factor, probably not HLA linked, is either protective in Asians and in Africans or, conversely, triggers an autoimmune reactivity that is possibly present in whites and absent in Asians and in Africans. HLA-A*29:02 transgenic mice in which a spontaneous posterior uveitis is observed after 6 months of age provide further evidence that the HLA-A29 molecule plays a role in the pathogenesis of the disease.
引用
收藏
页码:397 / 400
页数:4
相关论文
共 21 条
[1]  
BARONDES MJ, 1989, ANN OPHTHALMOL, V21, P306
[2]   Definition of the HLA-A29 peptide ligand motif allows prediction of potential T-cell epitopes from the retinal soluble antigen, a candidate autoantigen in birdshot retinopathy [J].
Boisgerault, F ;
Khalil, I ;
Tieng, V ;
Connan, F ;
Tabary, T ;
Cohen, JHM ;
Choppin, J ;
Charron, D ;
Toubert, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3466-3470
[3]   Pathological aspects of spontaneous uveitis and retinopathy in HLA-A29 transgenic mice and in animal models of retinal autoimmunity: Relevance to human pathologies [J].
de Kozak, Yvonne ;
Camelo, Serge ;
Pla, Marika .
OPHTHALMIC RESEARCH, 2008, 40 (3-4) :175-180
[4]   Different HLA class IA region complotypes for HLA-A29.2 and -A29.1 antigens, identical in birdshot retinochoroidopathy patients or healthy individuals [J].
Donvito, B ;
Monnet, D ;
Tabary, T ;
Delair, E ;
Vittier, M ;
Réveil, B ;
Sivaradjam, R ;
Edelson, C ;
Philbert, F ;
Brézin, AP ;
Cohen, JHM .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (09) :3227-3232
[5]   A New HLA Extended Haplotype Containing the A*2910 Allele in Birdshot Retinochoroidopathy: Susceptibility Narrowed to the HLA Molecule Itself [J].
Donvito, Beatrice ;
Monnet, Dominique ;
Tabary, Thierry ;
Delair, Emmanuelle ;
Vittier, Melanie ;
Reveil, Brigitte ;
Chiquet, Christophe ;
Brezin, Antoine P. ;
Cohen, Jacques H. M. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (05) :2525-2528
[6]  
FICH M, 1992, ACTA OPHTHALMOL, V70, P693
[7]   Birdshot retinochoroidopathy [J].
Gasch, AT ;
Smith, JA ;
Whitcup, SM .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1999, 83 (02) :241-249
[8]   Histopathology of birdshot retinochoroidopathy [J].
Gaudio, PA ;
Kaye, DB ;
Crawford, JB .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2002, 86 (12) :1439-1441
[9]   Uveitis Subtypes in a German Interdisciplinary Uveitis Center - Analysis of 1916 Patients [J].
Jakob, Eva ;
Reuland, Mirjam S. ;
Mackensen, Friederike ;
Harsch, Nadine ;
Fleckenstein, Monika ;
Lorenz, Hanns-Martin ;
Max, Regina ;
Becker, Matthias D. .
JOURNAL OF RHEUMATOLOGY, 2009, 36 (01) :127-136
[10]   Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals [J].
Levinson, R. D. ;
Du, Z. ;
Luo, L. ;
Monnet, D. ;
Tabary, T. ;
Brezin, A. P. ;
Zhao, L. ;
Gjertson, D. W. ;
Holland, G. N. ;
Reed, E. F. ;
Cohen, J. H. M. ;
Rajalingam, R. .
GENES AND IMMUNITY, 2008, 9 (03) :249-258