Tandem synthesis of 2-aryl-1,2,3-triazoles from α-arylhydrazonoketones with NH4OAc via copper-catalyzed aerobic oxidation

被引：32

作者：

Wu, Luyong ^{[1
]}

Guo, Shu ^{[1
]}

Wang, Xianghui ^{[1
]}

Guo, Zhifang ^{[1
]}

Yao, Guogui ^{[1
]}

Lin, Qiang ^{[1
]}

Wu, Mingshu ^{[1
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571158, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 17期

基金：

美国国家科学基金会;

关键词：

1,2,3-Triazoles; Hydrazonoketones; Copper-catalyzed; Aerobic oxidative; N-N bond; ONE-POT SYNTHESIS; CLICK CHEMISTRY; HIV-1; PROTEASE; CONVENIENT SYNTHESIS; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; IN-SITU; AZIDES; 1,2,3-TRIAZOLES; CYCLOADDITION;

D O I：

10.1016/j.tetlet.2015.03.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

convenient and efficient method for the synthesis of N-2-aryl 1,2,3-triazoles from alpha-arylhydrazonoketones under copper-catalyzed oxidative conditions has been developed. The tandem process comprises a condensation step of the carbonyl group with ammonium acetate and oxidative N-N bond formation in this transformation. The use of oxygen makes this transformation become more environmentally friendly. And various functional groups are well tolerated with the optimized reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2145 / 2148

页数：4

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