Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection

被引：3

作者：

Nguyen, Austin ^{[1
]}

Yusufali, Tasneem ^{[2
]}

Hollenbach, Jill A. ^{[2
,3
]}

Nellore, Abhinav ^{[1
,4
]}

Thompson, Reid F. ^{[1
,5
,6
,7
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97239 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[4] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA

[5] Oregon Hlth & Sci Univ, Dept Radiat Med, Portland, OR 97201 USA

[6] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA

[7] VA Portland Healthcare Syst, Div Hosp & Specialty Med, Portland, OR USA

来源：

HLA | 2022年 / 99卷 / 06期

关键词：

COVID-19; disease severity; HLA; antigen presentation; SARS-CoV-2; SUSCEPTIBILITY;

D O I：

10.1111/tan.14574

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancestry or age and in a pooled analysis. Overall, at the population level, we found HLA type is significantly less predictive of COVID-19 disease severity than certain demographic factors and clinical comorbidities.

引用

页码：607 / 613

页数：7

共 30 条

[1] A global reference for human genetic variation [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Wang, Jun ;

Wilson, Richard K. ;

Boerwinkle, Eric ;

Doddapaneni, Harsha ;

Han, Yi ;

Korchina, Viktoriya ;

Kovar, Christie ;

Lee, Sandra ;

Muzny, Donna ;

Reid, Jeffrey G. ;

Zhu, Yiming ;

Chang, Yuqi ;

Feng, Qiang ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Lan, Tianming ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Liu, Shengmao ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Tang, Meifang ;

Wang, Bo .

NATURE, 2015, 526 (7571) :68-+

[2] Data quality control in genetic case-control association studies [J].

Anderson, Carl A. ;

Pettersson, Fredrik H. ;

Clarke, Geraldine M. ;

Cardon, Lon R. ;

Morris, Andrew P. ;

Zondervan, Krina T. .

NATURE PROTOCOLS, 2010, 5 (09) :1564-1573

[3]

[Anonymous], 2021, ANC COVID 19 STUD

[4]

Arango M.-T., 2013, Autoimmunity: from Bench to Bedside

[5] HLA and Infectious Diseases [J].

Blackwell, Jenefer M. ;

Jamieson, Sarra E. ;

Burgner, David .

CLINICAL MICROBIOLOGY REVIEWS, 2009, 22 (02) :370-+

[6] HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy [J].

Couture, Alexandre ;

Garnier, Anthony ;

Docagne, Fabian ;

Boyer, Olivier ;

Vivien, Denis ;

Le-Mauff, Brigitte ;

Latouche, Jean-Baptiste ;

Toutirais, Olivier .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[7] Human Leukocyte Antigen (HLA) and immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate immune Response to Human immunodeficiency virus and Hepatitis C virus infections? [J].

Crux, Nicole B. ;

Elahi, Shokrollah .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[8] Genomewide Association Study of Severe Covid-19 with Respiratory Failure [J].

Ellinghaus, David ;

Degenhardt, Frauke ;

Bujanda, Luis ;

Buti, Maria ;

Albillos, Agustin ;

Invernizzi, Pietro ;

Fernandez, Javier ;

Prati, Daniele ;

Baselli, Guido ;

Asselta, Rosanna ;

Grimsrud, Marit M. ;

Milani, Chiara ;

Aziz, Fatima ;

Kassens, Jan ;

May, Sandra ;

Wendorff, Mareike ;

Wienbrandt, Lars ;

Uellendahl-Werth, Florian ;

Zheng, Tenghao ;

Yi, Xiaoli ;

de Pablo, Raul ;

Chercoles, Adolfo G. ;

Palom, Adriana ;

Garcia-Fernandez, Alba-Estela ;

Rodriguez-Frias, Francisco ;

Zanella, Alberto ;

Bandera, Alessandra ;

Protti, Alessandro ;

Aghemo, Alessio ;

Lleo, Ana ;

Biondi, Andrea ;

Caballero-Garralda, Andrea ;

Gori, Andrea ;

Tanck, Anja ;

Nolla, Anna Carreras ;

Latiano, Anna ;

Fracanzani, Anna Ludovica ;

Peschuck, Anna ;

Julia, Antonio ;

Pesenti, Antonio ;

Voza, Antonio ;

Jimenez, David ;

Mateos, Beatriz ;

Jimenez, Beatriz Nafria ;

Quereda, Carmen ;

Paccapelo, Cinzia ;

Gassner, Christoph ;

Angelini, Claudio ;

Cea, Cristina ;

Solier, Aurora .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) :1522-1534

[9] Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity Rate [J].

Ishii, Tomoo .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (12)

[10] Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients [J].

Iturrieta-Zuazo, Ignacio ;

Geraldine Rita, Claudia ;

Garcia-Soidan, Ana ;

de Malet Pintos-Fonseca, Ana ;

Alonso-Alarcon, Nieves ;

Pariente-Rodriguez, Roberto ;

Tejeda-Velarde, Amalia ;

Serrano-Villar, Sergio ;

Luis Castaner-Alabau, Jose ;

Nieto-Ganan, Israel .

CLINICAL IMMUNOLOGY, 2020, 219

← 1 2 3 →