The role of autophagy in cardiovascular pathology

被引：70
作者：
Gatica, Damian [1 ]
Chiong, Mario [2 ,3 ]
Lavandero, Sergio [2 ,3 ,4 ,5 ]
Klionsky, Daniel J. [1 ]
机构：
[1] Univ Michigan, Life Sci Inst, Dept Mol Cellular & Dev Biol, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA
[2] Univ Chile, Fac Ciencias Quim & Farmaceut, Adv Ctr Chron Dis ACCDiS, Dept Biochem & Mol Biol, Olivos 1007, Santiago 8380492, Chile
[3] Univ Chile, Fac Med, Olivos 1007, Santiago 8380492, Chile
[4] Corp Ctr Estudios Cient Enfermedades Cron CECEC, 926 JF Gonzalez, Santiago 7860201, Chile
[5] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX 75390 USA
来源：
CARDIOVASCULAR RESEARCH | 2022年 / 118卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Autophagosome; Cardiomyocyte; Heart; Lysosome; Vascular; ACTIVATED PROTEIN-KINASE; ENDOTHELIAL-CELL AUTOPHAGY; GROWTH-FACTOR-BETA; HEART-FAILURE; ENDOPLASMIC-RETICULUM; BECLIN; REGULATE AUTOPHAGY; SHEAR-STRESS; ULK1-MEDIATED PHOSPHORYLATION; DIABETIC CARDIOMYOPATHY;
D O I：
10.1093/cvr/cvab158
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which cytoplasmic components are sequestered, degraded, and recycled to survive various stress conditions. Autophagy dysregulation has been observed and linked with the development and progression of several pathologies, including cardiovascular diseases, the leading cause of death in the developed world. In this review, we aim to provide a broad understanding of the different molecular factors that govern autophagy regulation and how these mechanisms are involved in the development of specific cardiovascular pathologies, including ischemic and reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiac remodelling, and heart failure.
引用
收藏
页码：934 / 950
页数：17
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