Linezolid Toxicity and Mitochondrial Susceptibility: A Novel Neurological Complication in a Lebanese Patient

被引：14

作者：

Abou Hassan, Ossama K. ^{[1
]}

Karnib, Mohamad ^{[1
]}

El-Khoury, Riyad ^{[2
]}

Nemer, Georges ^{[3
]}

Ahdab-Barmada, Mamdouha ^{[2
]}

BouKhalil, Pierre ^{[1
]}

机构：

[1] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon

[2] Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, MMA Neuromuscular Diagnost Lab, Beirut, Lebanon

[3] Amer Univ Beirut, Dept Biochem & Mol Genet, Beirut, Lebanon

来源：

FRONTIERS IN PHARMACOLOGY | 2016年 / 7卷

关键词：

linezolid; toxicity; globus pallidus; mitochondria; J1; haplogroup; INDUCED LACTIC-ACIDOSIS; PROTEIN-SYNTHESIS; OXAZOLIDINONE ANTIBIOTICS; INHIBITION;

D O I：

10.3389/fphar.2016.00325

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recent rise in the use of linezolid to treat a variety of resistant pathogens has uncovered many side effects. Some patients develop lactic acidosis, myelosuppression, optic or peripheral neuropathies, and myopathies. We evaluated an elderly patient who presented to the Emergency Room with linezolid toxicity and a novel neurologic complication characterized by bilateral globi pallidi necrosis. Mitochondrial ribosome inhibition was described to be the predisposing factor. The patient belongs to the mitochondrial J1 haplotype known to be associated with side effects of the drug. We recommend based on the molecular profile of the illness pretreatment considerations and complication management.

引用

页数：5

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