Preclinical study of a controlled release oral morphine system in rats

被引：11

作者：

AlvarezFuentes, J ^{[1
]}

FernandezArevalo, M ^{[1
]}

Holgado, MA ^{[1
]}

Caraballo, I ^{[1
]}

Rabasco, AM ^{[1
]}

Mico, JA ^{[1
]}

Rojas, O ^{[1
]}

OrtegaAlvaro, A ^{[1
]}

机构：

[1] UNIV CADIZ,FAC MED,DEPT NEUROCIENCIAS,CADIZ,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 139卷 / 1-2期

关键词：

morphine hydrochloride; chronic pain; analgesia; severe pain; Eudragit(R) L30D; controlled release; MST Continus(R); tail flick test;

D O I：

10.1016/0378-5173(96)04612-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The efficiency of a new controlled release oral system containing morphine hydrochloride elaborated by introducing the drug into the polymeric structure of Eudragit(R) L30D is evaluated. Its in vitro dissolution behaviour and its effectiveness using the tail flick test model of pain in rats are investigated. A significant reduction in the drug release rate from the morphine-Eudragit(R) L30D complex as well as a very high efficiency in the dissolution process have been found. The tested morphine complex has an analgesic effect in rats. This effect is very clear from 30 min to 8 h. At 12 h the effect remains clear but with a lower level of statistical significance. Furthermore, there are no significative differences between the different doses tested.

引用

页码：237 / 241

页数：5

共 10 条

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