ROLE OF SPINDLE ASYMMETRY IN CELLULAR DYNAMICS

被引：14

作者：

Barral, Yves ^{[1
]}

Liakopoulos, Dimitris ^{[2
]}

机构：

[1] ETH Honggerberg, Inst Biochem, HPM, CH-8093 Zurich, Switzerland

[2] Heidelberg Univ, Zentrum Biochem, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 278 | 2009年 / 278卷

关键词：

Spindle asymmetry; Spindle positioning; Centrosomes; Spindle-pole bodies; Mitotic exit; Cell polarity; Cell division; C-ELEGANS EMBRYOS; HETEROTRIMERIC G-PROTEINS; SEPTATION INITIATION NETWORK; ANAPHASE-PROMOTING COMPLEX; POLE BODY INHERITANCE; CAENORHABDITIS-ELEGANS; MITOTIC EXIT; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; FISSION YEAST;

D O I：

10.1016/S1937-6448(09)78004-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitotic spindle is mostly perceived as a symmetric structure. However, in many cell divisions, the two poles of the spindle organize asters with different dynamics, associate with different biomolecules or subcellular domains, and perform different functions. In this chapter, we describe some of the most prominent examples of spindle asymmetry. These are encountered during cell-cycle progression in budding and fission yeast and during asymmetric cell divisions of stem cells and embryos. We analyze the molecular mechanisms that lead to generation of spindle asymmetry and discuss the importance of spindle-pole differentiation for the correct outcome of cell division.

引用

页码：149 / +

页数：67

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