Outcome prediction of enteral levodopa/carbidopa infusion in advanced Parkinson's disease

被引：12
作者：
Westin, J. [1 ]
Nyholm, D.
Groth, T.
Dougherty, M. S.
Yerramsetty, P. K.
Palhagen, S. E.
机构：
[1] Univ Uppsala Hosp, Dept Med Sci Biomed Informat & Engn, SE-75185 Uppsala, Sweden
[2] Dalarna Univ, Dept Culture Media & Comp Engn, SE-78188 Borlange, Sweden
[3] Uppsala Univ, Dept Neurosci, SE-75185 Uppsala, Sweden
[4] Karolinska Univ Hosp, Dept Neurol, SE-14186 Stockholm, Sweden
来源：
PARKINSONISM & RELATED DISORDERS | 2006年 / 12卷 / 08期
关键词：
Parkinson's disease; levodopa infusion; outcome prediction; improvement measure; predictive factor; continuous dopaminergic; stimulation;
D O I：
10.1016/j.parkreldis.2006.02.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Two studies comparing intraduodenal infusion of a levodopa/carbidopa gel with oral treatments in advanced PD patients demonstrated improvement in UPDRS scores and in frequent clinical ratings on a global treatment response scale. Further analysis of data from these studies was performed to find predictive factors related to degree of improvement with infusion. Pearson's correlation coefficients between measures of improvement and baseline variables were calculated. Using data from one study, a prediction model was designed and was then evaluated using the other Study's data. Correlations were found indicating that patients with more severe symptoms at baseline were most improved after infusion. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：509 / 513
页数：5
相关论文
共 11 条
[1]   Regression to the mean: what it is and how to deal with it [J].
Barnett, AG ;
van der Pols, JC ;
Dobson, AJ .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2005, 34 (01) :215-220
[2]   INTRADUODENAL INFUSION OF A WATER-BASED LEVODOPA DISPERSION FOR OPTIMIZATION OF THE THERAPEUTIC EFFECT IN SEVERE PARKINSONS-DISEASE [J].
BREDBERG, E ;
NILSSON, D ;
JOHANSSON, K ;
AQUILONIUS, SM ;
JOHNELS, B ;
NYSTROM, C ;
PAALZOW, L .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1993, 45 (02) :117-122
[3]  
Fahn S., RECENT DEV PARKINSON, V2, P153, DOI DOI 10.1002/ANA.410220556
[4]   UTILITY OF AN OBJECTIVE DYSKINESIA RATING-SCALE FOR PARKINSONS-DISEASE - INTERRATER AND INTRARATER RELIABILITY ASSESSMENT [J].
GOETZ, CG ;
STEBBINS, GT ;
SHALE, HM ;
LANG, AE ;
CHERNIK, DA ;
CHMURA, TA ;
AHLSKOG, JE ;
DORFLINGER, EE .
MOVEMENT DISORDERS, 1994, 9 (04) :390-394
[5]   Bilateral stimulation of the subthalamic nucleus in Parkinson's disease: Surgical efficacy and prediction of outcome [J].
Jaggi, JL ;
Umemura, A ;
Hurtig, HI ;
Siderowf, AD ;
Colcher, A ;
Stern, MB ;
Baltuch, GH .
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 2004, 82 (2-3) :104-114
[6]   DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSSOVER STUDY OF DUODENAL INFUSION OF LEVODOPA CARBIDOPA IN PARKINSONS-DISEASE PATIENTS WITH ON-OFF FLUCTUATIONS [J].
KURTH, MC ;
TETRUD, JW ;
TANNER, CM ;
IRWIN, I ;
STEBBINS, GT ;
GOETZ, CG ;
LANGSTON, JW .
NEUROLOGY, 1993, 43 (09) :1698-1703
[7]   Duodenal levodopa infusion in Parkinson's disease - long-term experience [J].
Nilsson, D ;
Nyholm, D ;
Aquilonius, SM .
ACTA NEUROLOGICA SCANDINAVICA, 2001, 104 (06) :343-348
[8]   Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease [J].
Nyholm, D ;
Remahl, AIMN ;
Dizdar, N ;
Constantinescu, R ;
Holmberg, B ;
Jansson, R ;
Aquilonius, SM ;
Askmark, H .
NEUROLOGY, 2005, 64 (02) :216-223
[9]   Optimizing levodopa phannacokinetics:: Intestinal infusion versus oral sustained-release tablets [J].
Nyholm, D ;
Askmark, H ;
Gomes-Trolin, C ;
Knutson, T ;
Lennernäs, H ;
Nyström, C ;
Aquilonius, SM .
CLINICAL NEUROPHARMACOLOGY, 2003, 26 (03) :156-163
[10]   Wireless real-time electronic data capture for self-assessment of motor function and quality of life in Parkinson's disease [J].
Nyholm, D ;
Kowalski, J ;
Aquilonius, SM .
MOVEMENT DISORDERS, 2004, 19 (04) :446-451
12