A chiral cobalt(II) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines

被引：11

作者：

Ma, Baiwei ^{[1
]}

Luo, Weiwei ^{[1
]}

Lin, Lili ^{[1
]}

Liu, Xiaohua ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 29期

基金：

中国国家自然科学基金;

关键词：

DIELS-ALDER REACTION; ENANTIOSELECTIVE SYNTHESIS; DIETHYL AZODICARBOXYLATE; 5-ALKOXYOXAZOLES; ALDEHYDES; OXAZOLES; 4-PHENYL-3H-1,2,4-TRIAZOLE-3,5(4H)-DIONE; AMINATION; LIGANDS; ESTERS;

D O I：

10.1039/c7cc01278k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient catalytic asymmetric formal [3+2] cycloaddition reaction of 5-alkoxyoxazoles with azodicarboxylate compounds has been realized by a chiral N, N'-dioxide/Co(BF4)(2)center dot 6H(2)O complex. A series of poly-substituted 1,2,4-triazolines compounds were obtained in moderate to excellent yields (70-99%) with excellent enantioselectivities (82-98% ee).

引用

收藏

页码：4077 / 4079

页数：3

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