Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex

被引：85

作者：

Liu, Xingguo ^{[1
]}

Hajnoczky, Gyoergy ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 10期

关键词：

Miro; Milton; Mitochondria; Motility; Fusion; Fission; Kinesin; Microtubule; Calcium; Pink1; OGT; KINESIN-ASSOCIATED PROTEIN; COIL DOMAIN PROTEINS; AXONAL-TRANSPORT; HEAVY-CHAIN; DROSOPHILA; MORPHOLOGY; CALCIUM; GTPASE; PINK1; DRP1;

D O I：

10.1016/j.biocel.2009.05.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium oscillations control mitochondrial motility along the microtubules and in turn, support on-demand distribution of mitochondria. However, the mechanism mediating the Ca2+ effect remained a mystery. Recently, several papers reported on the Ca2+-dependent regulation of mitochondrial dynamics by a Miro-Milton complex linking mitochondria to kinesin motors. Both mitochondrial motility and fusion-fission dynamics seem to be sensitive to a Ca2+-dependent switch by this complex. Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca2+-induced cell injury. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1972 / 1976

页数：5

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