SYNTHESIS, BIOLOGICAL EVALUATION AND INSILICO STUDIES OF THIENO[2,3-d]PYRIMIDINE-1,2,3-TRIAZOLES

被引：0

作者：

Nagaraju, Begari ^{[1
]}

Srinivasa, Vulichi R. ^{[2
]}

Triloknadh, Settyapalli ^{[1
]}

Kumari, Maddineni Aruna ^{[1
]}

Rajeswari, Muthirevula ^{[1
]}

Rao, Chunduri Venkata ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Sri Venkateswara Univ, Dept Biochem, Tirupati 517502, Andhra Pradesh, India

来源：

HETEROCYCLIC LETTERS | 2022年 / 12卷 / 04期

关键词：

Click-chemistry; Azides Heterocycles; Thienopyrimidine-1; 2; 3-triazole; CLICK CHEMISTRY; IN-VITRO; DRUG DISCOVERY; DERIVATIVES; TRIAZOLE; 1,2,3-TRIAZOLES; DESIGN; MOTIFS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and development of novel therapeutic candidates is an ever-demanding area to tackle various communicable and non-communicable diseases. By considering the pharmaceutical importance of thienopyrimidines and 1,2,3-triazoles, in the present study we have attempted the synthesis of thieno[2,3-d]pyrimidine tethered 1,2,3-triazoles(6a-j) through click-chemistry approach in reliable yields (80-92%) under Cu (I) promoted azide-alkyne cycloaddition (CuAAC). Further all the synthesized compounds were successfully established through 1H, 13C NMR and Mass spectral characterization. Finally, we presume that our study could set a stage for the identification of potential hits which could facilitate the development a wide array of renowned therapeutic classes with a promising clinical significance.

引用

页码：831 / 843

页数：13

共 42 条

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