Core-Shell-Structured Covalent-Organic Framework as a Nanoagent for Single-Laser-Induced Phototherapy

被引：46

作者：

Feng, Jie ^{[1
]}

Ren, Wen-Xiu ^{[1
]}

Gao, Jia-Lin ^{[1
]}

Li, Fei ^{[1
]}

Kong, Fei ^{[1
]}

Yao, Bing-Jian ^{[1
]}

Dong, Yu-Bin ^{[1
]}

机构：

[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 15期

基金：

中国博士后科学基金;

关键词：

covalent-organic framework; single laser irradiation; NIR phototherapy; multi-modal imaging; theranostics; NANOPLATFORM; NANOSHEETS; NANOCRYSTALS; FLUORESCENCE; STRATEGIES; THERAPY; AGENT;

D O I：

10.1021/acsami.1c01125

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Imaging-guided phototherapy, including photothermal therapy and photodynamic therapy, has been emerging as a promising avenue for precision cancer treatment. However, the utilization of a single laser to induce combination phototherapy and multiple-model imaging remains a great challenge. Herein, we report, the first of its kind, a covalent-organic framework (COF)based magnetic core-shell nanocomposite, Fe3O4@COF-DhaTph, that is used as a multifunctional nanoagent for cancer theranostics under single 660 nm NIR irradiation. Besides significant photothermal and photodynamic effects, it still permits triple-modal magnetic resonance/ photoacoustic/near-infrared thermal (IR) imaging due to its unequaled magnetic and optical performance. We believe that the results obtained herein could obviously promote the application of COF-based multifunctional nanomaterials in cancer theranostics.

引用

页码：17243 / 17254

页数：12

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