Advances in research on Zika virus

被引:24
作者
Ali, Amjad [1 ]
Wahid, Braira [1 ]
Rafique, Shazia [1 ]
Idrees, Muhammad [1 ,2 ]
机构
[1] Univ Punjab, Ctr Appl Mol Biol, 87 West Canal Bank Rd Thokar Niaz Baig, Lahore 53700, Pakistan
[2] Hazara Univ, Mansehra, Pakistan
关键词
Zika virus; Molecular evolution; Neurological complications; Transmission; Diagnosis; Pathogenesis; SEXUAL TRANSMISSION; FRENCH-POLYNESIA; STRUCTURAL BASIS; WEST-NILE; INFECTION; OUTBREAK; DENGUE; VACCINE; BRAIN; LEADS;
D O I
10.1016/j.apjtm.2017.03.020
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence. neurological complications and other teratogenic outcomes as well as pathogenesis.
引用
收藏
页码:301 / 312
页数:12
相关论文
共 91 条
[1]   Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication [J].
Aagaard, Kjersti M. ;
Lahon, Anismrita ;
Suter, Melissa A. ;
Arya, Ravi P. ;
Seferovic, Maxim D. ;
Vogt, Megan B. ;
Hu, Min ;
Stossi, Fabio ;
Mancini, Michael A. ;
Harris, R. Alan ;
Kahr, Maike ;
Eppes, Catherine ;
Rac, Martha ;
Belfort, Michael A. ;
Park, Chun Shik ;
Lacorazza, Daniel ;
Rico-Hesse, Rebecca .
SCIENTIFIC REPORTS, 2017, 7
[2]   Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys [J].
Abbink, Peter ;
Larocca, Rafael A. ;
De La Barrera, Rafael A. ;
Bricault, Christine A. ;
Moseley, Edward T. ;
Boyd, Michael ;
Kirilova, Marinela ;
Li, Zhenfeng ;
Ng'ang'a, David ;
Nanayakkara, Ovini ;
Nityanandam, Ramya ;
Mercado, Noe B. ;
Borducchi, Erica N. ;
Agarwal, Arshi ;
Brinkman, Amanda L. ;
Cabral, Crystal ;
Chandrashekar, Abishek ;
Giglio, Patricia B. ;
Jetton, David ;
Jimenez, Jessica ;
Lee, Benjamin C. ;
Mojta, Shanell ;
Molloy, Katherine ;
Shetty, Mayuri ;
Neubauer, George H. ;
Stephenson, Kathryn E. ;
Peron, Jean Pierre S. ;
Zanotto, Paolo M. de A. ;
Misamore, Johnathan ;
Finneyfrock, Brad ;
Lewis, Mark G. ;
Alter, Galit ;
Modjarrad, Kayvon ;
Jarman, Richard G. ;
Eckels, Kenneth H. ;
Michael, Nelson L. ;
Thomas, Stephen J. ;
Barouch, Dan H. .
SCIENCE, 2016, 353 (6304) :1129-1132
[3]   Phylogenetic Analysis of the NS5 Gene of Zika Virus [J].
Adiga, Rama .
JOURNAL OF MEDICAL VIROLOGY, 2016, 88 (10) :1821-1826
[4]  
Awasthi S., 2016, J ANTIVIR ANTIRETROV, V8, P61, DOI DOI 10.4172/JAA.1000E130
[5]   Ultrastructure of Zika virus particles in cell cultures [J].
Barreto-Vieira, Debora Ferreira ;
Barth, Ortrud Monika ;
da Silva, Marcos Alexandre Nunes ;
Santos, Carolina Cardoso ;
Santos, Aline da Silva ;
Joaquim Batista, F. Filho ;
Bispo de Filippis, Ana Maria .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2016, 111 (08) :532-534
[6]   Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016 [J].
Barzon, L. ;
Pacenti, M. ;
Berto, A. ;
Sinigaglia, A. ;
Franchin, E. ;
Lavezzo, E. ;
Brugnaro, P. ;
Palu, G. .
EUROSURVEILLANCE, 2016, 21 (10) :2-6
[7]   Isolation of Infective Zika Virus from Urine and Saliva of Patients in Brazil [J].
Bonaldo, Myrna C. ;
Ribeiro, Ieda P. ;
Lima, Noemia S. ;
dos Santos, Alexandre A. C. ;
Menezes, Lidiane S. R. ;
da Cruz, Stephanie O. D. ;
de Mello, Iasmim S. ;
Furtado, Nathalia D. ;
de Moura, Elaine E. ;
Damasceno, Luana ;
da Silva, Kely A. B. ;
de Castro, Marcia G. ;
Gerber, Alexandra L. ;
de Almeida, Luiz G. P. ;
Lourenco-de-Oliveira, Ricardo ;
Vasconcelos, Ana Tereza R. ;
Brasil, Patricia .
PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (06)
[8]   Extended surface for membrane association in Zika virus NS1 structure [J].
Brown, W. Clay ;
Akey, David L. ;
Konwerski, Jamie R. ;
Tarrasch, Jeffrey T. ;
Skiniotis, Georgios ;
Kuhn, Richard J. ;
Smith, Janet L. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 23 (09) :865-867
[9]   The mitotic spindle: linking teratogenic effects of Zika virus with human genetics? [J].
Bullerdiek, Joern ;
Dotzauer, Andreas ;
Bauer, Ingrid .
MOLECULAR CYTOGENETICS, 2016, 9
[10]   Zika Virus Outbreak, Bahia, Brazil [J].
Campos, Gubio S. ;
Bandeira, Antonio C. ;
Sardi, Silvia I. .
EMERGING INFECTIOUS DISEASES, 2015, 21 (10) :1885-1886