Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder

被引：1

作者：

Akaishi, Tetsuya ^{[1
,2
]}

Himori, Noriko ^{[3
]}

Takeshita, Takayuki ^{[3
]}

Fujihara, Kazuo ^{[4
]}

Misu, Tatsuro ^{[1
]}

Takahashi, Toshiyuki ^{[1
,5
]}

Fujimori, Juichi ^{[6
]}

Ishii, Tadashi ^{[2
]}

Aoki, Masashi ^{[1
]}

Nakazawa, Toru ^{[3
]}

Nakashima, Ichiro ^{[6
]}

机构：

[1] Tohoku Univ, Dept Neurol, Grad Sch Med, Sendai, Miyagi, Japan

[2] Tohoku Univ Hosp, Dept Educ & Support Reg Med, Sendai, Miyagi, Japan

[3] Tohoku Univ, Dept Ophthalmol, Grad Sch Med, Sendai, Miyagi, Japan

[4] Fukushima Med Univ, Dept Multiple Sclerosis Therapeut, Fukushima, Japan

[5] Natl Hosp Org Yonezawa Natl Hosp, Dept Neurol, Yonezawa, Yamagata, Japan

[6] Tohoku Med & Pharmaceut Univ, Dept Neurol, Sendai, Miyagi, Japan

来源：

BRAIN AND BEHAVIOR | 2021年 / 11卷 / 05期

关键词：

anti‐ aquaporin‐ 4; antibodies; neuromyelitis optica spectrum disorders; ocular trauma; optic neuritis; MULTIPLE-SCLEROSIS; AQUAPORIN-4; ANTIBODY; INJURY; RISK; NEUROPATHY; MARKER; NMO;

D O I：

10.1002/brb3.2083

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Methods Herein, we present three patients who developed acute optic neuritis with visual disturbances after accidental minor trauma to their eyes, without any fundus abnormality or orbital floor fractures present. Results Two of the three patients had a preceding history of neurological disturbances compatible with NMOSD (e.g., myelitis, area postrema syndrome) before the occurrence of trauma. One patient was rapidly treated with steroid pulse therapy and plasmapheresis, and he fully recovered visual acuity. The other two, who were left untreated in the acute phase, had sequelae of severe visual disturbances in the affected eyes. Conclusions These cases suggest possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti-AQP4 antibodies. Avoiding ocular trauma and early administration of steroid pulse therapy in response to optic neuritis after trauma are desired in such cases.

引用

页数：6

共 22 条

[1] Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders [J].