Natural inhibitors targeting osteoclast-mediated bone resorption

被引：15
|
作者：
Zeng, Guang-Zhi
Tan, Ning-Hua [1 ]
Hao, Xiao-Jiang
Mu, Quan-Zhang
Li, Rong-Tao
机构：
[1] Chinese Acad Sci, State Key Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China
[2] Chinese Acad Sci, Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 24期
基金：
中国国家自然科学基金;
关键词：
cathepsin K; matrix metalloproteinase 9; alpha v beta(3); natural inhibitor; bone resorption;
D O I：
10.1016/j.bmcl.2006.09.042
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6178 / 6180
页数：3
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