Association of Interleukin-10-1082A/G Polymorphism with Idiopathic Recurrent Miscarriage: A Systematic Review and Meta-Analysis

被引：4
作者：
Peng, Zheng [1 ]
Lv, Xiaolan [2 ]
Sun, Yifan [3 ]
Dai, Shengming [1 ]
机构：
[1] Guangxi Med Univ, Affiliated Hosp 4, Dept Clin Lab, Liuzhou 545000, Guangxi, Peoples R China
[2] Liuzhou Matern & Child Healthcare Hosp, Dept Clin Lab, Liuzhou, Guangxi, Peoples R China
[3] Liuzhou Hosp Tradit Chinese Med, Dept Clin Lab, Liuzhou, Guangxi, Peoples R China
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2016年 / 75卷 / 02期
关键词：
Idiopathic recurrent miscarriage; IL-10; meta-analysis; polymorphism; CYTOKINE GENE POLYMORPHISMS; PREGNANCY LOSS; PROMOTER POLYMORPHISM; IL-10; WOMEN; DEFICIENCY;
D O I：
10.1111/aji.12467
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Problem This systematic review and meta-analysis aimed to synthesize and assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) using relevant studies. Method of study Five electronic databases (Cochrane Library of Systematic Reviews, PubMed, EMBASE, Web of Science, and Google Scholar) were comprehensively searched up to August 2015. Data were extracted independently by two members of our team. Results The meta-analysis of 13 eligible studies suggested a recessive effect of the G allele (-1082A/G polymorphism) for IRM risk. Conclusions The pooled evidence demonstrated that the GG genotype increased IRM risk.
引用
收藏
页码：162 / 171
页数：10
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