Identification of a new prostate cancer susceptibility locus on chromosome 8q24

被引：179

作者：

Yeager, Meredith ^{[1
,2
]}

Chatterjee, Nilanjan ^{[2
]}

Ciampa, Julia ^{[2
]}

Jacobs, Kevin B. ^{[3
]}

Gonzalez-Bosquet, Jesus ^{[2
]}

Hayes, Richard B. ^{[2
]}

Kraft, Peter ^{[4
]}

Wacholder, Sholom ^{[2
]}

Orr, Nick ^{[2
]}

Berndt, Sonja ^{[2
]}

Yu, Kai ^{[2
]}

Hutchinson, Amy ^{[1
,2
]}

Wang, Zhaoming ^{[1
,2
]}

Amundadottir, Laufey ^{[2
]}

Feigelson, Heather Spencer ^{[5
]}

Thun, Michael J. ^{[5
]}

Diver, W. Ryan ^{[5
]}

Albanes, Demetrius ^{[2
]}

Virtamo, Jarmo ^{[6
]}

Weinstein, Stephanie ^{[2
]}

Schumacher, Fredrick R. ^{[4
,7
]}

Cancel-Tassin, Geraldine ^{[8
]}

Cussenot, Olivier ^{[8
]}

Valeri, Antoine ^{[8
]}

Andriole, Gerald L. ^{[9
]}

Crawford, E. David ^{[10
]}

Haiman, Christopher A. ^{[11
]}

Henderson, Brian ^{[11
]}

Kolonel, Laurence ^{[12
]}

Le Marchand, Loic ^{[12
]}

Siddiq, Afshan ^{[13
]}

Riboli, Elio ^{[13
]}

Key, Timothy J. ^{[14
]}

Kaaks, Rudolf ^{[15
]}

Isaacs, William ^{[16
]}

Isaacs, Sarah ^{[16
]}

Wiley, Kathleen E. ^{[16
]}

Gronberg, Henrik ^{[17
]}

Wiklund, Fredrik ^{[17
]}

Stattin, Par ^{[18
]}

Xu, Jianfeng ^{[19
]}

Zheng, S. Lilly ^{[19
]}

Sun, Jielin ^{[19
]}

Vatten, Lars J. ^{[20
]}

Hveem, Kristian ^{[20
]}

Kumle, Merethe ^{[21
]}

Tucker, Margaret ^{[2
]}

Gerhard, Daniela S. ^{[22
]}

Hoover, Robert N. ^{[2
]}

Fraumeni, Joseph F., Jr. ^{[2
]}

机构：

[1] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA

[2] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA

[3] Bioinformed Consulting Serv, Gaithersburg, MD USA

[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

[5] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA

[6] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[7] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[8] Hop Tenon, CeRePP, AP HP, F-75970 Paris, France

[9] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA

[10] Univ Colorado Denver & Hlth Sci Ctr, Dept Surg, Denver, CO USA

[11] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA

[12] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[13] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[14] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[15] German Canc Res Ctr, Div Clin Epidemiol, DKFZ, D-6900 Heidelberg, Germany

[16] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

[17] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[18] Umea Univ, Dept Surg Preoperat Sci Urol & Androl, Umea, Sweden

[19] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA

[20] Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway

[21] Univ Tromso, Inst Community Med, Tromso, Norway

[22] NCI, Off Canc Genom, NIH, DHHS, Bethesda, MD 20892 USA

[23] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Sch Med, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 10期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; COLORECTAL-CANCER; MULTIPLE LOCI; RISK; VARIANT; RANGE; SCAN;

D O I：

10.1038/ng.444

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

引用

页码：1055 / 1057

页数：3

共 15 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk [J].

Berndt, Sonja I. ;

Potter, John D. ;

Hazra, Aditi ;

Yeager, Meredith ;

Thomas, Gilles ;

Makar, Karen W. ;

Welch, Robert ;

Cross, Amanda J. ;

Huang, Wen-Yi ;

Schoen, Robert E. ;

Giovannucci, Edward ;

Chan, Andrew T. ;

Chanock, Stephen J. ;

Peters, Ulrike ;

Hunter, David J. ;

Hayes, Richard B. .

HUMAN MOLECULAR GENETICS, 2008, 17 (17) :2665-2672

[3] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[4] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[5] Multiple loci with different cancer specificities within the 8q24 gene desert [J].

Ghoussaini, Maya ;

Song, Honglin ;

Koessler, Thibaud ;

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Driver, Kristy E. ;

Pooley, Karen A. ;

Ramus, Susan J. ;

Kjaer, Susanne Krueger ;

Hogdall, Estrid ;

DiCioccio, Richard A. ;

Whittemore, Alice S. ;

Gayther, Simon A. ;

Giles, Graham G. ;

Guy, Michelle ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Brown, Paul M. ;

Hopper, John L. ;

Neal, David E. ;

Pharoah, Paul D. P. ;

Ponder, Bruce A. J. ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Dunning, Alison M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (13) :962-966

[6] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[7] A common genetic risk factor for colorectal and prostate cancer [J].

Haiman, Christopher A. ;

Le Marchand, Loic ;

Yamamato, Jennifer ;

Stram, Daniel O. ;

Sheng, Xin ;

Kolonel, Laurence N. ;

Wu, Anna H. ;

Reich, David ;

Henderson, Brian E. .

NATURE GENETICS, 2007, 39 (08) :954-956

[8] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[9] Sequence variant on 8q24 confers susceptibility to urinary bladder cancer [J].

Kiemeney, Lambertus A. ;

Thorlacius, Steinunn ;

Sulem, Patrick ;

Geller, Frank ;

Aben, Katja K. H. ;

Stacey, Simon N. ;

Gudmundsson, Julius ;

Jakobsdottir, Margret ;

Bergthorsson, Jon T. ;

Sigurdsson, Asgeir ;

Blondal, Thorarinn ;

Witjes, J. Alfred ;

Vermeulen, Sita H. ;

Hulsbergen-van de Kaa, Christina A. ;

Swinkels, Dorine W. ;

Ploeg, Martine ;

Cornel, Erik B. ;

Vergunst, Henk ;

Thorgeirsson, Thorgeir E. ;

Gudbjartsson, Daniel ;

Gudjonsson, Sigurjon A. ;

Thorleifsson, Gudmar ;

Kristinsson, Kari T. ;

Mouy, Magali ;

Snorradottir, Steinunn ;

Placidi, Donatella ;

Campagna, Marcello ;

Arici, Cecilia ;

Koppova, Kvetoslava ;

Gurzau, Eugene ;

Rudnai, Peter ;

Kellen, Eliane ;

Polidoro, Silvia ;

Guarrera, Simonetta ;

Sacerdote, Carlotta ;

Sanchez, Manuel ;

Saez, Berta ;

Valdivia, Gabriel ;

Ryk, Charlotta ;

de Verdier, Petra ;

Lindblom, Annika ;

Golka, Klaus ;

Bishop, D. Timothy ;

Knowles, Margaret A. ;

Nikulasson, Sigfus ;

Petursdottir, Vigdis ;

Jonsson, Eirikur ;

Geirsson, Gudmundur ;

Kristjansson, Baldvin ;

Mayordomo, Jose I. .

NATURE GENETICS, 2008, 40 (11) :1307-1312

[10] The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer [J].

Pomerantz, Mark M. ;

Ahmadiyeh, Nasim ;

Jia, Li ;

Herman, Paula ;

Verzi, Michael P. ;

Doddapaneni, Harshavardhan ;

Beckwith, Christine A. ;

Chan, Jennifer A. ;

Hills, Adam ;

Davis, Matt ;

Yao, Keluo ;

Kehoe, Sarah M. ;

Lenz, Heinz-Josef ;

Haiman, Christopher A. ;

Yan, Chunli ;

Henderson, Brian E. ;

Frenkel, Baruch ;

Barretina, Jordi ;

Bass, Adam ;

Tabernero, Josep ;

Baselga, Jose ;

Regan, Meredith M. ;

Manak, J. Robert ;

Shivdasani, Ramesh ;

Coetzee, Gerhard A. ;

Freedman, Matthew L. .

NATURE GENETICS, 2009, 41 (08) :882-884

← 1 2 →

共 15 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk [J].

Berndt, Sonja I. ;

Potter, John D. ;

Hazra, Aditi ;

Yeager, Meredith ;

Thomas, Gilles ;

Makar, Karen W. ;

Welch, Robert ;

Cross, Amanda J. ;

Huang, Wen-Yi ;

Schoen, Robert E. ;

Giovannucci, Edward ;

Chan, Andrew T. ;

Chanock, Stephen J. ;

Peters, Ulrike ;

Hunter, David J. ;

Hayes, Richard B. .

HUMAN MOLECULAR GENETICS, 2008, 17 (17) :2665-2672

[3] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[4] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[5] Multiple loci with different cancer specificities within the 8q24 gene desert [J].

Ghoussaini, Maya ;

Song, Honglin ;

Koessler, Thibaud ;

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Driver, Kristy E. ;

Pooley, Karen A. ;

Ramus, Susan J. ;

Kjaer, Susanne Krueger ;

Hogdall, Estrid ;

DiCioccio, Richard A. ;

Whittemore, Alice S. ;

Gayther, Simon A. ;

Giles, Graham G. ;

Guy, Michelle ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Brown, Paul M. ;

Hopper, John L. ;

Neal, David E. ;

Pharoah, Paul D. P. ;

Ponder, Bruce A. J. ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Dunning, Alison M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (13) :962-966

[6] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[7] A common genetic risk factor for colorectal and prostate cancer [J].

Haiman, Christopher A. ;

Le Marchand, Loic ;

Yamamato, Jennifer ;

Stram, Daniel O. ;

Sheng, Xin ;

Kolonel, Laurence N. ;

Wu, Anna H. ;

Reich, David ;

Henderson, Brian E. .

NATURE GENETICS, 2007, 39 (08) :954-956

[8] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[9] Sequence variant on 8q24 confers susceptibility to urinary bladder cancer [J].

Kiemeney, Lambertus A. ;

Thorlacius, Steinunn ;

Sulem, Patrick ;

Geller, Frank ;

Aben, Katja K. H. ;

Stacey, Simon N. ;

Gudmundsson, Julius ;

Jakobsdottir, Margret ;

Bergthorsson, Jon T. ;

Sigurdsson, Asgeir ;

Blondal, Thorarinn ;

Witjes, J. Alfred ;

Vermeulen, Sita H. ;

Hulsbergen-van de Kaa, Christina A. ;

Swinkels, Dorine W. ;

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