Interhospital dissemination of KPC-3 producing-Klebsiella pneumoniae ST512. Detection by MALDI-TOF

被引：1

作者：

Angeles Asencio-Egea, Maria ^{[1
]}

Gaitan-Pitera, Jorge ^{[1
]}

Huertas-Vaquero, Maria ^{[1
]}

Carranza-Gonzalez, Rafael ^{[1
]}

Roman-Ortiz, Carmen ^{[2
]}

Lara-Fuella, Noelia ^{[3
]}

机构：

[1] Hosp Gen La Mancha Ctr, Lab Microbiol, Ciudad Real, Spain

[2] Hosp Gen La Mancha Ctr, Serv Med Prevent, Ciudad Real, Spain

[3] ISCIII, Lab Resistencia Antibiot, Ctr Nacl Microbiol, Madrid, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2021年 / 39卷 / 02期

关键词：

Carbapenemase-producing Klebsiella pneumoniae; KPC; MALDI-TOF; CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; DESORPTION IONIZATION-TIME; RAPID DETECTION; OUTBREAK; SPAIN;

D O I：

10.1016/j.eimc.2019.12.014

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction/Objective: To describe an outbreak of KPC-3-producing Klebsiella pneumoniae (KPN) and determine the diagnostic efficacy of MALDI-TOF in its detection. Methods: Retrospective study of the KPC-3-KPN isolated in 2 hospitals in Ciudad Real. The peak at 11,109 kDa + 15 was sought in the KPN spectra provided by MALDI-TOF. Results: We isolated 156 KPN strains that carried the bla(Kpc-3) gene, with a unique profile belonging to ST512 (31 strains studied). There was 25% of infected patients, 84% were nosocomial or related to health care and 93% had some underlying disease (31% of exitus in the first month). The detection of the peak showed 90% sensitivity and 100% specificity. Conclusions: We detected the clonal spread of a KPN ST512 strain producing KPC-3 in 3 hospitals in Ciudad Real. In addition, we show the profitability of MALDI-TOF in the early detection of KPC-KPN. (C) 2020 Elsevier Espafia, S.L.U. and Sociedad Espaiiola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.

引用

页码：83 / 86

页数：4

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