Streptococcus pneumoniae induces secretion of vascular endothelial growth factor by human neutrophils

被引：30

作者：

van der Flier, M

Coenjaerts, F

Kimpen, JLL

Hoepelman, AM

Geelen, SPM

机构：

[1] Univ Utrecht, Wilhelmina Childrens Hosp, Ctr Med, NL-3508 AB Utrecht, Netherlands

[2] Univ Utrecht, Eijkman Winkler Inst Microbiol, Ctr Med, NL-3508 AB Utrecht, Netherlands

[3] Univ Utrecht, Med Ctr, Dept Internal Med, Div Infect Dis & AIDS, NL-3508 AB Utrecht, Netherlands

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 08期

关键词：

D O I：

10.1128/IAI.68.8.4792-4794.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection by pneumococci causes an acute inflammatory response associated with neutrophil influx, increased vascular permeability, and edema. Vascular endothelial growth factor (VEGF) is one of the most potent regulators of endothelial permeability. In vitro stimulation of neutrophils showed that pneumococci and purified pneumococcal cell wall induce VEGF secretion, independent of the presence of pneumolysin or polysaccharide capsule. The results of this study indicate VEGF is secreted in pneumococcal disease, suggesting a role as a mediator of increased vascular permeability.

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收藏

页码：4792 / 4794

页数：3

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