Effectiveness and Safety of Long-Term Dupilumab Treatment in Elderly Patients with Atopic Dermatitis: A Multicenter Real-Life Observational Study

被引：57

作者：

Patruno, Cataldo ^{[1
]}

Fabbrocini, Gabriella ^{[2
]}

Longo, Giuseppe ^{[3
]}

Argenziano, Giuseppe ^{[4
]}

Ferrucci, Silvia Mariel ^{[5
]}

Stingeni, Luca ^{[6
]}

Peris, Ketty ^{[7
]}

Ortoncelli, Michela ^{[8
]}

Offidani, Annamaria ^{[9
]}

Amoruso, Giuseppe Fabrizio ^{[10
]}

Talamonti, Marina ^{[11
]}

Girolomoni, Giampiero ^{[12
]}

Grieco, Teresa ^{[13
]}

Iannone, Michela ^{[14
]}

Nettis, Eustachio ^{[15
]}

Foti, Caterina ^{[16
]}

Rongioletti, Franco ^{[17
]}

Corazza, Monica ^{[18
]}

Veneri, Michele Delli ^{[3
]}

Napolitano, Maddalena ^{[19
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[2] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, Naples, Italy

[3] Univ Naples Federico II, Dept Phys, Naples, Italy

[4] Univ Campania, Dermatol Unit, Naples, Italy

[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[6] Univ Perugia, Dept Med, Dermatol Sect, Perugia, Italy

[7] Univ Cattolica Sacro Cuore, IRCCS, Fdn Policlin Univ A Gemelli, Dermatol, Rome, Italy

[8] Univ Turin, Dermatol Clin, Turin, Italy

[9] Polytech Marche Univ, Dermatol Unit, Dept Clin & Mol Sci, Ancona, Italy

[10] AO Cosenza, UOC Dermatol, Cosenza, Italy

[11] Tor Vergata Univ Rome, Dept System Med, Policlin Tor Vergata, Dermatol Unit, Rome, Italy

[12] Univ Verona, Dept Med, Sect Dermatol, Verona, Italy

[13] Sapienza Univ Rome, Dermatol Unit, Rome, Italy

[14] Univ Pisa, Dept Dermatol, Pisa, Italy

[15] Univ Bari Aldo Moro, Sch & Chair Allergol & Clin Immunol, Dept Emergency & Organ Transplantat, Bari, Italy

[16] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy

[17] Univ Cagliari, Dept Med Sci & Publ Hlth, Unit Dermatol, Cagliari, Italy

[18] Univ Ferrara, Sect Dermatol & Infect Dis, Dept Med Sci, Ferrara, Italy

[19] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Via Francesco Santis Snc, I-86100 Campobasso, Italy

来源：

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2021年 / 22卷 / 04期

关键词：

MODERATE;

D O I：

10.1007/s40257-021-00597-5

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objective The objective of this study was to assess the effectiveness and safety of dupilumab in treating elderly patients with atopic dermatitis from baseline to 52 weeks. Methods A retrospective observational real-life study was conducted in a group of elderly patients with severe atopic dermatitis treated with dupilumab for 52 weeks. Inclusion criteria were: age >= 65 years; diagnosis of atopic dermatitis made by an expert dermatologist; Eczema Area and Severity Index >= 24; and a contraindication, side effects, or failure to respond to cyclosporine. The primary outcome was the mean percentage reduction in the Eczema Area and Severity Index score from baseline to week 52. Secondary measures included the mean percentage reduction in the Pruritus and Sleep Numerical Rating Scales and the Dermatology Life Quality Index, and the types and rates of adverse events from baseline to week 52. Results One hundred and five patients were eligible for the study. Flexural dermatitis was the most frequent clinical phenotype (63.8%). The coexistence of more than one clinical phenotype was found in 70/105 (66.6%) patients. We observed a reduction in all disease severity scores from baseline to week 52 (p < 0.001). Adverse events were recorded in 30/105 (28.6%) patients, with conjunctivitis and injection-site reaction the most frequent. Conclusions In this study, dupilumab is an effective and safe treatment for the long-term management of atopic dermatitis in patients aged over 65 years.

引用

页码：581 / 586

页数：6

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