Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

被引：26

作者：

Ekineker, Guelcin ^{[1
]}

Nguyen, Christophe ^{[2
]}

Bayir, Suemeyra ^{[1
]}

Dominguez Gil, Sofia ^{[3
]}

Isci, Umit ^{[1
]}

Daurat, Morgane ^{[2
]}

Godefroy, Anastasia ^{[2
,4
]}

Raehm, Laurence ^{[3
]}

Charnay, Clarence ^{[3
]}

Oliviero, Erwan ^{[3
]}

Ahsen, Vefa ^{[1
]}

Gary-Bobo, Magali ^{[2
]}

Durand, Jean-Olivier ^{[3
]}

Dumoulin, Fabienne ^{[1
]}

机构：

[1] Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey

[2] Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France

[3] CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France

[4] NanoMedSyn, 15 Ave Charles Flahault, F-34093 Montpellier 05, France

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 77期

关键词：

D O I：

10.1039/c9cc05703j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.

引用

页码：11619 / 11622

页数：4

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