Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis

被引:31
作者
Kaminska, Halla [1 ]
Szarpak, Lukasz [2 ,6 ]
Kosior, Dariusz [3 ,10 ,11 ]
Wieczorek, Wojciech [4 ]
Szarpak, Agnieszka [5 ]
Al-Jeabory, Mahdi [6 ]
Gawel, Wladyslaw [7 ]
Gasecka, Aleksandra [8 ,12 ,13 ]
Jaguszewski, Milosz J. [9 ]
Jarosz-Chobot, Przemyslawa [1 ]
机构
[1] Med Univ Silesia, Fac Med Sci Katowice, Dept Pediat & Childrens Diabetol, Silesia, Poland
[2] Maria Sklodowska Curie Bialystok Oncol Ctr, Ogrodowa 12 Str, PL-15027 Bialystok, Poland
[3] Cardinal Stefan Wyszynski Univ, Coll Med, Fac Med, Warsaw, Poland
[4] Med Univ Warsaw, Dept Emergency Med, Warsaw, Poland
[5] Maria Sklodowska Curie Med Acad Warsaw, Warsaw, Poland
[6] Polish Soc Disaster Med, Warsaw, Poland
[7] Silesian Hosp Opava, Dept Surg, Opava, Czech Republic
[8] Univ Med Ctr Utrecht, Dept Cardiol, Utrecht, Netherlands
[9] Med Univ Gdansk, Dept Cardiol 1, Gdansk, Poland
[10] Minist Interior & Adm Warsaw, Dept Cardiol, Cent Clin Hosp, Warsaw, Poland
[11] Minist Interior & Adm Warsaw, Hypertens Electrophysiol Lab, Cent Clin Hosp, Warsaw, Poland
[12] Univ Amsterdam, Lab Expt Clin Chem, Med Ctr, Amsterdam, Netherlands
[13] Med Univ Warsaw, Chair & Dept Cardiol 1, Warsaw, Poland
关键词
Diabetes mellitus; COVID-19; SARS-CoV-2; Systematic review; Meta-analysis; Mortality; Hospitalization; CORONAVIRUS DISEASE 2019; INFECTION; OUTCOMES; BURDEN;
D O I
10.1007/s00592-021-01701-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The novel coronavirus disease 2019 (COVID-19) has spread worldwide since the beginning of 2020, placing the heavy burden on the health systems all over the world. The population that particularly has been affected by the pandemic is the group of patients suffering from diabetes mellitus. Having taken the public health in considerations, we have decided to perform a systematic review and meta-analysis of diabetes mellitus on in-hospital mortality in patients with COVID-19. Methods A systematic literature review (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane) including all published clinical trials or observational studies published till December 10, 2020, was performed using following terms "diabetes mellitus" OR "diabetes" OR "DM" AND "survival" OR "mortality" AND "SARS-CoV-2" OR "COVID-19". Results Nineteen studies were included out of the 7327 initially identified studies. Mortality of DM patients vs non-DM patients was 21.3 versus 6.1%, respectively (OR = 2.39; 95%CI: 1.65, 3.64; P < 0.001), while severe disease in DM and non-DM group varied and amounted to 34.8% versus 22.8% (OR = 1.43; 95%CI: 0.82, 2.50; P = 0.20). In the DM group, the complications were observed far more often when compared with non-DM group, both in acute respiratory distress (31.4 vs. 17.2%; OR = 2.38; 95%CI:1.80, 3.13; P < 0.001), acute cardiac injury (22.0% vs. 12.8%; OR = 2.59; 95%CI: 1.81, 3.73; P < 0.001), and acute kidney injury (19.1 vs. 10.2%; OR = 1.97; 95%CI: 1.36, 2.85; P < 0.001). Conclusions Based on the findings, we shall conclude that diabetes is an independent risk factor of the severity of COVID-19 in-hospital settings; therefore, patients with diabetes shall aim to reduce the exposure to the potential infection of COVID-19.
引用
收藏
页码:1101 / 1110
页数:10
相关论文
共 52 条
  • [1] Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes
    Acharya, Dilaram
    Lee, Kwan
    Lee, Dong Seok
    Lee, Yun Sik
    Moon, Seong-Su
    [J]. HEALTHCARE, 2020, 8 (03)
  • [2] Characteristics and outcomes ofCOVID-19 in hospitalized patients with and without diabetes
    Al-Salameh, Abdallah
    Lanoix, Jean-Philippe
    Bennis, Youssef
    Andrejak, Claire
    Brochot, Etienne
    Deschasse, Guillaume
    Dupont, Herve
    Goeb, Vincent
    Jaureguy, Maite
    Lion, Sylvie
    Maizel, Julien
    Moyet, Julien
    Vaysse, Benoit
    Desailloud, Rachel
    Ganry, Olivier
    Schmit, Jean-Luc
    Lalau, Jean-Daniel
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2021, 37 (03)
  • [3] Diabetes Mellitus, Hypertension, and Death among 32 Patients with MERS-CoV Infection, Saudi Arabia
    Alanazi, Khalid H.
    Abedi, Glen R.
    Midgley, Claire M.
    Alkhamis, Abdulrahim
    Alsaqer, Taghreed
    Almoaddi, Abdullah
    Algwizani, Abdullah
    Ghazal, Sameeh S.
    Assiri, Abdullah M.
    Jokhdar, Hani
    Gerber, Susan I.
    Alabdely, Hail
    Watson, John T.
    [J]. EMERGING INFECTIOUS DISEASES, 2020, 26 (01) : 166 - 168
  • [4] Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severeCOVID-19 in type 2 diabetes
    Alzaid, Fawaz
    Julla, Jean-Baptiste
    Diedisheim, Marc
    Potier, Charline
    Potier, Louis
    Velho, Gilberto
    Gaborit, Benedicte
    Manivet, Philippe
    Germain, Stephane
    Vidal-Trecan, Tiphaine
    Roussel, Ronan
    Riveline, Jean-Pierre
    Dalmas, Elise
    Venteclef, Nicolas
    Gautier, Jean-Francois
    [J]. EMBO MOLECULAR MEDICINE, 2020, 12 (10)
  • [5] American Diabetes Association, 2020, Clin Diabetes, V38, P10, DOI 10.2337/cd20-as01
  • [6] [Anonymous], 2020, COVID-19 significantly impacts health services for noncommunicable diseases
  • [7] Costs of COVID-19 pandemic associated with diabetes in Europe: a health care cost model
    Bain, Stephen C.
    Czernichow, Sebastien
    Bogelund, Mette
    Madsen, Maria Elmegaard
    Yssing, Cecilie
    McMillan, Annabell Cajus
    Hvid, Christian
    Hettiarachchige, Nadilka
    Panton, Ulrik Haagen
    [J]. CURRENT MEDICAL RESEARCH AND OPINION, 2021, 37 (01) : 27 - 36
  • [8] Hospitalization costs and complications in hospitalized patients with type 2 diabetes mellitus in Beijing, China
    Bao, Xiaoyuan
    Yang, Chao
    Fang, Kai
    Shi, Moye
    Yu, Guopei
    Hu, Yonghua
    [J]. JOURNAL OF DIABETES, 2017, 9 (04) : 405 - 411
  • [9] Dysglycemia and long-term mortality: observations from the Israel study of glucose intolerance, obesity and hypertension
    Bergman, Michael
    Chetrit, Angela
    Roth, Jesse
    Dankner, Rachel
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2015, 31 (04) : 368 - 375
  • [10] Practical recommendations for the management of diabetes in patients with COVID-19
    Bornstein, Stefan R.
    Rubino, Francesco
    Khunti, Kamlesh
    Mingrone, Geltrude
    Hopkins, David
    Birkenfeld, Andreas L.
    Boehm, Bernhard
    Amiel, Stephanie
    Holt, Richard I. G.
    Skyler, Jay S.
    DeVries, J. Hans
    Renard, Eric
    Eckel, Robert H.
    Zimmet, Paul
    George Alberti, Kurt
    Vidal, Josep
    Geloneze, Bruno
    Chan, Juliana C.
    Ji, Linong
    Ludwig, Barbara
    [J]. LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (06) : 546 - 550