Induction of DNA damage responses by T-oligo and 6-thio-dG via modulating telomere associated proteins and telomerase

被引：2

作者：

Schrank, Zachary ^{[1
]}

Khan, Nabiha ^{[1
]}

Kellen, Joseph ^{[1
]}

Singh, Sanjana ^{[1
]}

Osude, Chike ^{[1
]}

Puri, Neelu ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Rockford, IL 61107 USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2019-2965

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2965

引用

页数：2

共 4 条

[1] T-oligo mediates DNA damage responses by modulating telomere associated proteins and telomerase [J].

Khan, Nabiha Haleema ;

Schrank, Zachary ;

Kellen, Joseph ;

Singh, Sanjana ;

Osude, Chike ;

Puri, Neelu ;

Chhabra, Gagan .

CANCER RESEARCH, 2018, 78 (13)

[2] The novel, telomerase-directed, telomere-targeted, anticancer agent 6-thio-dG (THIO) demonstrates potent activity and induces antitumor immunity in hepatocellular carcinoma (HCC) models [J].

Shay, J. ;

Mender, I. ;

Siteni, S. ;

Obrocea, M. ;

Vitoc, V. ;

Gryaznov, S. .

EUROPEAN JOURNAL OF CANCER, 2022, 174 :S30-S31

[3] T-oligo therapy for NSCLC: induction of DNA damage response, senescence, apoptosis, and xenograft tumor growth reduction [J].

Puri, Neelu ;

Mulnix, Richard ;

Pitman, Ryan ;

Salgia, Ravi .

CANCER RESEARCH, 2009, 69

[4] Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses [J].

Hanedi, Abdalla ;

Burkitt, Michael D. ;

Williams, Jonathan M. ;

Duckworth, Carrie A. ;

Caamano, Jorge ;

Pritchard, D. M. .

GASTROENTEROLOGY, 2013, 144 (05) :S136-S136

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