Repeatability of tumor blood flow quantification with 82Rubidium PET/CT in prostate cancer-a test-retest study

BackgroundNon-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measurement with the widely used positron emission tomography (PET) flow tracer (82)Rubidium (Rb-82). However, no test-retest data is available for TBF measurement with Rb-82 PET in prostate cancer. Such information is important to determine the potential clinical usefulness of the technique. The aim of the present study was to determine the test-retest repeatability of TBF measurement with both dynamic and static Rb-82 PET.MethodsWe recruited 10 low-to-high-risk prostate cancer patients scheduled for clinical prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) or magnetic resonance imaging. Pelvic and cardiac static and dynamic Rb-82 PET/CT were performed at baseline and repeated on a different day within 1week. In total, 11 primary lesions were analyzed.ResultsFor K1, standardized uptake values (SUV)max, SUVmean, and SUVpeak, prostate cancer Rb-82 PET TBF has a repeatability of 32%, 51%, 53%, and 58% and an intraclass correlation of 0.98, 0.89, 0.88, and 0.88, respectively.ConclusionDynamic Rb-82 PET/CT with kinetic modeling measures TBF in prostate cancer with high repeatability, which allows identification of blood flow changes of 32%. Static late-uptake Rb-82 PET/CT is inferior, and only intra-individual blood flow changes above 51% can hence be recognized.